| Protein Name | Abl tyrosine kinase |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 45821 |
| Gene Symbol | Abl |
| UniProt | P00522 (ABL_DROME), M9PFI5 (M9PFI5_DROME), M9PCT8 (M9PCT8_DROME), M9PFS1 (M9PFS1_DROME), M9PCU1 (M9PCU1_DROME), X2JGR4 (X2JGR4_DROME), A8JNU2 (A8JNU2_DROME), M9PFI8 (M9PFI8_DROME), M9PI83 (M9PI83_DROME), M9PFX0 (M9PFX0_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
6
Total Number of Articles : 20 |
Description |
Abl tyrosine kinase |
| Gene Summary |
Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including cell morphogenesis involved in differentiation; protein phosphorylation; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including apical cortex; cell-cell junction; and muscle tendon junction. Is extrinsic component of plasma membrane. Colocalizes with contractile ring. Is expressed in several structures, including adepithelial cell; adult brain; ovary; photoreceptor cell; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022] |
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