Protein Name hydroxymethylbilane synthase
Organism Rattus norvegicus
Gene ID 25709
Gene Symbol

Hmbs

UniProt Q5M893 (Q5M893_RAT)
Relationships Total Number of functionally related compound(s) : 19
Total Number of Articles : 15
Description

hydroxymethylbilane synthase

Gene Summary

Enables several functions, including amine binding activity; hydroxymethylbilane synthase activity; and uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to lead ion; and response to estradiol. Located in axon; condensed chromosome; and perinuclear region of cytoplasm. Biomarker of bilirubin metabolic disorder and liver carcinoma. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • porphobilinogen deaminase
  • alternative name: porphobilinogen deaminase
  • pre-uroporphyrinogen synthase
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Properties