| Protein Name | F-box and leucine rich repeat protein 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 25827 |
| Gene Symbol | FBXL2 |
| UniProt | Q9UKC9 (FBXL2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
9
Total Number of Articles : 8 |
Description |
F-box and leucine rich repeat protein 2 |
| Gene Summary |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
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