| Protein Name | glutathione-disulfide reductase |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 116686 |
| Gene Symbol | Gsr |
| UniProt | F1LRE1 (F1LRE1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
577
Total Number of Articles : 1024 |
Description |
glutathione-disulfide reductase |
| Gene Summary |
Enables several functions, including glutathione binding activity; glutathione-disulfide reductase (NADPH) activity; and nucleotide binding activity. Involved in several processes, including response to iron(III) ion; response to ischemia; and response to vitamin A. Predicted to be located in external side of plasma membrane. Predicted to be active in cytosol and mitochondrion. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including acute kidney failure (multiple); artery disease (multiple); hemorrhagic cystitis; myoglobinuria; and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 10 and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Jun 2025] |
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