| Protein Name | notch 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18129 |
| Gene Symbol | Notch2 |
| UniProt | O35516 (NOTC2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
68
Total Number of Articles : 62 |
Description |
notch 2 |
| Gene Summary |
Enables NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including left/right pattern formation; marginal zone B cell differentiation; and nephron development. Acts upstream of or within several processes, including activation of protein kinase B activity; cholangiocyte proliferation; and liver development. Located in cilium; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |