Protein Name tripartite motif containing 37
Organism Homo sapiens
Gene ID 4591
Gene Symbol


UniProt O94972 (TRI37_HUMAN)
Relationships Total Number of functionally related compound(s) : 203
Total Number of Articles : 199

tripartite motif containing 37

Gene Summary

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]

  • E3 ubiquitin-protein ligase TRIM37
  • RING-B-box-coiled-coil protein
  • RING-type E3 ubiquitin transferase TRIM37
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