Protein Name MYC binding protein 2
Organism Homo sapiens
Gene ID 23077
Gene Symbol

MYCBP2

UniProt O75592 (MYCB2_HUMAN)
Relationships Total Number of functionally related compound(s) : 64
Total Number of Articles : 40
Description

MYC binding protein 2

Gene Summary

This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]

synonyms
  • E3 ubiquitin-protein ligase MYCBP2
  • Highwire
  • MYC binding protein 2, E3 ubiquitin protein ligase
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Properties