Protein Name 5'-3' exoribonuclease 1
Organism Mus musculus
Gene ID 24127
Gene Symbol

Xrn1

UniProt A0A087WQN7 (A0A087WQN7_MOUSE), F8VQ87 (F8VQ87_MOUSE)
Relationships Total Number of functionally related compound(s) : 100
Total Number of Articles : 67
Description

5'-3' exoribonuclease 1

Gene Summary

Enables 5'-3' RNA exonuclease activity; G-quadruplex DNA binding activity; and G-quadruplex RNA binding activity. Predicted to be involved in RNA catabolic process and negative regulation of translation. Located in P-body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human XRN1 (5'-3' exoribonuclease 1). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • 5'-3' exoribonuclease 1
  • protein Dhm2
  • strand-exchange protein 1 homolog
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Properties