Protein Name lysyl oxidase
Organism Rattus norvegicus
Gene ID 24914
Gene Symbol

Lox

UniProt P16636 (LYOX_RAT)
Relationships Total Number of functionally related compound(s) : 186
Total Number of Articles : 138
Description

lysyl oxidase

Gene Summary

Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in extracellular matrix organization; response to steroid hormone; and response to xenobiotic stimulus. Acts upstream of or within cell chemotaxis; platelet-derived growth factor receptor-beta signaling pathway; and protein oxidation. Located in extracellular matrix. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; colon adenocarcinoma; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • protein-lysine 6-oxidase
  • Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)
  • H-rev142
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Properties