Protein Name glutamate-cysteine ligase, catalytic subunit
Organism Mus musculus
Gene ID 14629
Gene Symbol

Gclc

UniProt P97494 (GSH1_MOUSE), Q3TEF1 (Q3TEF1_MOUSE), Q3UNA7 (Q3UNA7_MOUSE)
Relationships Total Number of functionally related compound(s) : 104
Total Number of Articles : 132
Description

glutamate-cysteine ligase, catalytic subunit

Gene Summary

Enables glutamate-cysteine ligase activity. Acts upstream of or within several processes, including glutathione biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of protein metabolic process. Located in cytosol. Part of glutamate-cysteine ligase complex. Is expressed in several structures, including alimentary system; central nervous system; integumental system; metanephros; and sensory organ. Used to study cataract. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 7; cystic fibrosis; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • glutamate--cysteine ligase catalytic subunit
  • GCS heavy chain
  • gamma GCS-HS
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Properties