cathepsin K ; Rattus norvegicus






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1 9286755 Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo. J Bone Miner Res 1997 Sep 2
2 10430032 Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones. Biol Chem 1999 Jun 7
3 10673380 Structure-based development of pyridoxal propionate derivatives as specific inhibitors of cathepsin K in vitro and in vivo. Biochem Biophys Res Commun 2000 Jan 27 3
4 10967538 Bisphosphonate administration alters subcellular localization of vacuolar-type H(+)-ATPase and cathepsin K in osteoclasts during experimental movement of rat molars. Anat Rec 2000 Sep 1 4
5 11311061 Azepanone-based inhibitors of human and rat cathepsin K. J Med Chem 2001 Apr 26 1
6 11938609 A cysteine protease inhibitor prevents suspension-induced declines in bone weight and strength in rats. J Physiol Anthropol Appl Human Sci 2002 Jan 1
7 11996914 A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat. Bone 2002 May 2
8 12650749 Complementary use of ion trap/time-of-flight mass spectrometry in combination with capillary high-pressure liquid chromatography: early characterization of in vivo metabolites of the cathepsin K inhibitor NVP-AAV490 in rat. J Chromatogr B Analyt Technol Biomed Life Sci 2003 Apr 25 2
9 14527964 Blockade of the sympathetic nervous system degrades ligament in a rat MCL model. J Appl Physiol (1985) 2004 Feb 2
10 14736240 Design of potent, selective, and orally bioavailable inhibitors of cysteine protease cathepsin k. J Med Chem 2004 Jan 29 3
11 15542040 Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts. Bone 2004 Nov 2
12 15896958 Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 2005 Jun 15 6
13 15929988 Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts. J Biol Chem 2005 Aug 5 5
14 15982880 P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 2005 Aug 1 3
15 16290936 Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg Med Chem Lett 2006 Feb 15 6
16 16302794 Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J Med Chem 2005 Dec 1 1
17 16302795 Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem 2005 Dec 1 3
18 16509577 Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. J Med Chem 2006 Mar 9 2
19 16622732 High-turnover osteoporosis is induced by cyclosporin A in rats. J Bone Miner Metab 2006 1
20 16699068 An orally active cathepsin K inhibitor, furan-2-carboxylic acid, 1-{1-[4-fluoro-2-(2-oxo-pyrrolidin-1-yl)-phenyl]-3-oxo-piperidin-4-ylcarbamoyl}-cyclohexyl)-amide (OST-4077), inhibits osteoclast activity in vitro and bone loss in ovariectomized rats. J Pharmacol Exp Ther 2006 Aug 3
21 17916452 Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats. Bone 2007 Dec 1
22 18572405 Discovery of selective and nonpeptidic cathepsin S inhibitors. Bioorg Med Chem Lett 2008 Jul 15 1
23 18664521 Species differences between human and rat in the substrate specificity of cathepsin K. J Biochem 2008 Oct 1
24 18707091 Effect of cathepsin K inhibitors on bone resorption. J Med Chem 2008 Sep 11 2
25 18758923 Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E(1) to promote bone formation in aged, estrogen-deficient rats. Pharm Res 2008 Dec 3
26 19699734 Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. Eur J Pharmacol 2009 Oct 25 1
27 20149657 Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg Med Chem Lett 2010 Mar 1 2
28 21806983 Administration of zinc inhibits osteoclastogenesis through the suppression of RANK expression in bone. Eur J Pharmacol 2011 Oct 1 1
29 21950592 Low dose of propranolol down-modulates bone resorption by inhibiting inflammation and osteoclast differentiation. Br J Pharmacol 2012 Apr 1
30 22576626 Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Int J Mol Med 2012 Jul 1
31 23243450 Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional chinese medicinal formula, on osteoclastic bone resorption. Evid Based Complement Alternat Med 2012 1
32 23529168 Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy. Hypertension 2013 Jun 1
33 23543761 Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation. J Immunol 2013 May 1 2
34 23735664 Zinc supplementation inhibits the increase in osteoclastogenesis and decrease in osteoblastogenesis in streptozotocin-induced diabetic rats. Eur J Pharmacol 2013 Aug 15 1
35 24317478 ONO-5334, a cathepsin K inhibitor, improves bone strength by preferentially increasing cortical bone mass in ovariectomized rats. J Bone Miner Metab 2014 Nov 1
36 24743169 Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk. PLoS One 2014 1
37 24819928 Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and up-regulates OPG in an experimental periodontitis model. PLoS One 2014 2
38 24879020 Galnon, a galanin receptor agonist, improves intrinsic cortical bone tissue properties but exacerbates bone loss in an ovariectomised rat model. J Musculoskelet Neuronal Interact 2014 Jun 1
39 25036175 Drynaria total flavonoids decrease cathepsin K expression in ovariectomized rats. Genet Mol Res 2014 Jun 9 4
40 25557511 Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model. J Pharm Pharmacol 2015 Feb 1
41 25636877 Antiosteoporotic activity and constituents of Podocarpium podocarpum. Phytomedicine 2015 Jan 15 1
42 25990199 Cathepsin K Inhibitor Regulates Inflammation and Bone Destruction in Experimentally Induced Rat Periapical Lesions. J Endod 2015 Sep 1
43 26694734 Effects of combined ovariectomy with dexamethasone on rat lumbar vertebrae. Menopause 2016 Apr 4
44 27154501 Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model. Acta Biomater 2016 Jul 15 1
45 27245552 The novel bisphosphonate disodium dihydrogen-4-[(methylthio) phenylthio] methanebisphosphonate increases bone mass in post-ovariectomy rats. J Pharmacol Sci 2016 May 1
46 27578589 [Role of epithelial sodium channel in rat osteoclast differentiation and bone resorption]. Nan Fang Yi Ke Da Xue Xue Bao 2016 Aug 20 1
47 27981392 Histological evidence that metformin reverses the adverse effects of diabetes on orthodontic tooth movement in rats. J Mol Histol 2017 Apr 1
48 28465233 Aesculin modulates bone metabolism by suppressing receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and transduction signals. Biochem Biophys Res Commun 2017 Jun 17 1
49 28703398 Tissue dynamics and regenerative outcome in two resorbable non-cross-linked collagen membranes for guided bone regeneration: A preclinical molecular and histological study in vivo. Clin Oral Implants Res 2018 Jan 2
50 28878388 Promotion effect of extracts from plastrum testudinis on alendronate against glucocorticoid-induced osteoporosis in rat spine. Sci Rep 2017 Sep 6 2