lysine demethylase 4C ; Homo sapiens






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1 15138608 Identification and characterization of JMJD2 family genes in silico. Int J Oncol 2004 Jun 2
2 16732293 The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature 2006 Jul 20 1
3 19732750 Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene. Biochem Biophys Res Commun 2009 Nov 13 1
4 19784073 Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. Oncogene 2009 Dec 17 1
5 20684604 Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem 2010 Aug 12 5
6 21156283 Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell 2010 Dec 14 2
7 21575637 Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases. FEBS Lett 2011 Jun 23 2
8 21859682 High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases. J Biomol Screen 2012 Jan 2
9 22420752 Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. FEBS J 2012 Jun 1
10 22917519 Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C). Bioorg Med Chem Lett 2012 Sep 15 2
11 23129632 Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci U S A 2012 Dec 4 1
12 23384557 The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer. Mol Oncol 2013 Jun 1
13 23692052 Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy. Biochemistry 2013 Jun 18 2
14 23884959 Hypoxia enhances the expression of prostate-specific antigen by modifying the quantity and catalytic activity of Jumonji C domain-containing histone demethylases. Carcinogenesis 2013 Dec 1
15 24371038 GASC1 expression in lung carcinoma is associated with smoking and prognosis of squamous cell carcinoma. Histol Histopathol 2014 Jun 3
16 24394434 Phospho-ΔNp63α/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. Cell Cycle 2014 1
17 24936217 Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res 2014 1
18 24952432 A polymorphism in JMJD2C alters the cleavage by caspase-3 and the prognosis of human breast cancer. Oncotarget 2014 Jul 15 1
19 25014588 Substrate- and cofactor-independent inhibition of histone demethylase KDM4C. ACS Chem Biol 2014 Sep 19 3
20 26747609 Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C). J Biol Chem 2016 Mar 18 2
21 26774480 KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism. Cell Rep 2016 Jan 26 5
22 27295953 Synthesis and Characterisation of Substrate-Based Peptides as Inhibitors of Histone Demethylase KDM4C. Protein Pept Lett 2016 1
23 27742014 KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression. Neoplasia 2016 Oct 1
24 28236704 Jumonji domain containing 2C promotes cell migration and invasion through modulating CUL4A expression in lung cancer. Biomed Pharmacother 2017 May 3
25 28396876 Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C. J Diabetes Res 2017 5
26 29207681 Histone demethylase JMJD2C: epigenetic regulators in tumors. Oncotarget 2017 Oct 31 3
27 29718303 The KDM4A/KDM4C/NF-κB and WDR5 epigenetic cascade regulates the activation of B cells. Nucleic Acids Res 2018 Jun 20 1
28 30132131 Genetic alterations of 9p24 in lymphomas and their impact for cancer (immuno-)therapy. Virchows Arch 2019 Apr 2
29 30537731 circZMYM2 Competed Endogenously with miR-335-5p to Regulate JMJD2C in Pancreatic Cancer. Cell Physiol Biochem 2018 3
30 30640062 Sufficiency of hypoxia-inducible 2-oxoglutarate dioxygenases to block chemical oxidative stress-induced differentiation of human embryonic stem cells. Stem Cell Res 2019 Jan 3
31 31270335 Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun 2019 Jul 3 1
32 31665047 JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway. J Exp Clin Cancer Res 2019 Oct 29 1
33 31766290 Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc. Cancers (Basel) 2019 Nov 13 1
34 31784197 Rational design, synthesis and biological profiling of new KDM4C inhibitors. Bioorg Med Chem 2020 Jan 1 1
35 32972441 microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis. J Exp Clin Cancer Res 2020 Sep 24 1
36 33413524 Correction to: microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis. J Exp Clin Cancer Res 2021 Jan 7 1
37 33649841 GASC1 promotes glioma progression by enhancing NOTCH1 signaling. Mol Med Rep 2021 May 1
38 35414503 Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway. Ann Clin Lab Sci 2022 Mar 1
39 35468881 JMJD2C mediates the MDM2/p53/IL5RA axis to promote CDDP resistance in uveal melanoma. Cell Death Discov 2022 Apr 25 2