ryanodine receptor 2, cardiac ; Mus musculus






194 Article(s)
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1 9600932 In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation. Proc Natl Acad Sci U S A 1998 May 26 1
2 11429443 Molecular basis of Ca(2)+ activation of the mouse cardiac Ca(2)+ release channel (ryanodine receptor). J Gen Physiol 2001 Jul 2
3 14557272 Residue Gln4863 within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction. J Biol Chem 2003 Dec 19 2
4 14593104 The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gating. J Biol Chem 2004 Jan 30 1
5 14695257 Imaging single cardiac ryanodine receptor Ca2+ fluxes in lipid bilayers. Biophys J 2004 Jan 4
6 14985349 Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes. J Biol Chem 2004 May 14 3
7 15890976 Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor. Circ Res 2005 May 27 3
8 15894801 Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. J Biol Chem 2005 Jul 15 9
9 15955866 The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance. Mol Pharmacol 2005 Sep 4
10 16049053 Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6. Am J Physiol Cell Physiol 2005 Dec 3
11 16204356 Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J 2005 Dec 1
12 16407108 Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A 2006 Jan 17 4
13 16481613 Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A 2006 Feb 28 5
14 16672364 Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A 2006 May 16 2
15 16678258 Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells. Cell Calcium 2006 Jul 3
16 16787580 Localized Ca2+ uncaging induces Ca2+ release through IP3R in smooth muscle. Acta Pharmacol Sin 2006 Jul 1
17 16825580 Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model. Circ Res 2006 Aug 4 1
18 16873551 Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A 2006 Aug 8 7
19 17363382 Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle. J Physiol 2007 Jul 15 5
20 17404231 Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci U S A 2007 Apr 10 1
21 17578347 Molecular and electrophysiological bases of catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Electrophysiol 2007 Jul 1
22 17607358 Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. J Clin Invest 2007 Jul 2
23 17702390 [Cyclic nucleotide phosphodiesterase IV expression, activity and targeting in cells of cardiovascular system]. Yao Xue Xue Bao 2007 Jun 3
24 17872467 Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circ Res 2007 Nov 9 1
25 17925380 RyR1-specific requirement for depolarization-induced Ca2+ sparks in urinary bladder smooth muscle. J Cell Sci 2007 Nov 1 1
26 18419777 Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts. Acta Physiol (Oxf) 2008 Oct 1
27 18441289 Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes. Learn Mem 2008 May 1
28 18598963 Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm 2008 Jul 1
29 18845675 Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release. Mol Pharmacol 2009 Jan 2
30 19096022 Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia. Circ Res 2009 Jan 30 2
31 19298530 The decrease of expression of ryanodine receptor sub-type 2 is reversed by gentamycin sulphate in vascular myocytes from mdx mice. J Cell Mol Med 2009 Sep 4
32 19578067 Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res 2009 Nov 1 1
33 19835880 Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. J Mol Cell Cardiol 2010 Feb 4
34 20009080 Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol 2009 Dec 1
35 20451249 Ca(2+) release induced by cADP-ribose is mediated by FKBP12.6 proteins in mouse bladder smooth muscle. Cell Calcium 2010 May 1
36 20538074 Purkinje cell calcium dysregulation is the cellular mechanism that underlies catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 2010 Aug 4
37 20595652 Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy. Circ Res 2010 Aug 20 3
38 20621925 Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts. Cardiovasc Res 2011 Mar 1 1
39 20652277 Caffeine-induced Ca(2+) signaling as an index of cardiac progenitor cells differentiation. Basic Res Cardiol 2010 Nov 1
40 20676041 Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Channels (Austin) 2010 Jul-Aug 2
41 20797399 Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure. J Mol Cell Cardiol 2011 Jan 4
42 20807279 Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation. J Cardiovasc Electrophysiol 2011 Mar 1
43 20937285 Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia. J Mol Cell Cardiol 2011 Jan 2
44 20944434 Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model. Circ J 2010 Nov 4
45 20947503 Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor. J Biol Chem 2010 Dec 17 3
46 21099115 Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest 2010 Dec 1
47 21099118 Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest 2010 Dec 9
48 21099119 Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure? J Clin Invest 2010 Dec 7
49 21113126 Ryanodine receptor-2 upregulation and nicotine-mediated plasticity. EMBO J 2011 Jan 5 3
50 21151160 Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway. Acta Pharmacol Sin 2011 Jan 1