| 1 | 10818225 | The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. | FEBS Lett | 2000 May 19 |
1 |
| 2 | 11000516 | The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone. | Mol Cell Endocrinol | 2000 Sep 25 |
1 |
| 3 | 11309494 | Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10. | Proc Natl Acad Sci U S A | 2001 May 8 |
4 |
| 4 | 11334139 | ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes. | Antisense Nucleic Acid Drug Dev | 2001 Apr |
1 |
| 5 | 11477090 | The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. | J Biol Chem | 2001 Oct 12 |
4 |
| 6 | 12475894 | ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. | FASEB J | 2003 Feb |
1 |
| 7 | 12714508 | The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. | Blood | 2003 Aug 15 |
4 |
| 8 | 12755693 | Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation. | Eur J Biochem | 2003 Jun |
1 |
| 9 | 12832423 | Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). | J Biol Chem | 2003 Oct 3 |
2 |
| 10 | 14713188 | Modeling of enzyme-substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10. | J Comput Aided Mol Des | 2003 Sep |
1 |
| 11 | 14734484 | Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP. | Clin Cancer Res | 2004 Jan 1 |
3 |
| 12 | 15182369 | The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein. | Eur J Biochem | 2004 Jun |
2 |
| 13 | 15341532 | Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines. | J Neurochem | 2004 Sep |
3 |
| 14 | 15777180 | Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. | Comb Chem High Throughput Screen | 2005 Mar |
4 |
| 15 | 15972296 | Genomic structure and functional characterization of the human ADAM10 promoter. | FASEB J | 2005 Sep |
1 |
| 16 | 16229685 | A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. | Biochem J | 2006 Feb 1 |
2 |
| 17 | 16239146 | Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. | Cell | 2005 Oct 21 |
1 |
| 18 | 16309826 | Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma. | Cancer Lett | 2007 Jan 8 |
2 |
| 19 | 16687212 | Characterization of sequential N-cadherin cleavage by ADAM10 and PS1. | Neurosci Lett | 2006 Jul 24 |
1 |
| 20 | 16735514 | ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells. | J Biol Chem | 2006 Jul 28 |
1 |
| 21 | 17047365 | Alpha-secretase activation--an approach to Alzheimer's disease therapy. | Neurodegener Dis | 2006 |
1 |
| 22 | 17079736 | Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. | Mol Biol Cell | 2007 Jan |
1 |
| 23 | 17428795 | Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. | J Biol Chem | 2007 Jun 1 |
2 |
| 24 | 17548045 | Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. | Anal Biochem | 2007 Jul 15 |
9 |
| 25 | 17548644 | Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes. | J Immunol | 2007 Jun 15 |
1 |
| 26 | 17650113 | New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity. | Eur J Neurosci | 2007 Jul |
1 |
| 27 | 17727679 | Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer. | Cancer Sci | 2007 Nov |
2 |
| 28 | 17908044 | Alpha-secretase as a therapeutic target. | Curr Alzheimer Res | 2007 Sep |
3 |
| 29 | 17986385 | PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid. | Biochem Biophys Res Commun | 2008 Jan 11 |
2 |
| 30 | 18036818 | Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis. | Bioorg Med Chem Lett | 2008 Jan 1 |
1 |
| 31 | 18381078 | Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme. | Biochim Biophys Acta | 2008 Jun |
7 |
| 32 | 18420943 | ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin. | Circ Res | 2008 May 23 |
2 |
| 33 | 18658095 | ERK1/2 mediate wounding- and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding. | Invest Ophthalmol Vis Sci | 2009 Jan |
2 |
| 34 | 18952609 | Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases. | J Biol Chem | 2008 Dec 19 |
1 |
| 35 | 19091752 | Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. | J Biol Chem | 2009 Feb 6 |
1 |
| 36 | 19144697 | Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin. | FASEB J | 2009 Jun |
10 |
| 37 | 19183255 | A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10. | J Neurochem | 2009 Mar |
1 |
| 38 | 19411314 | Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. | Am J Physiol Lung Cell Mol Physiol | 2009 Jul |
2 |
| 39 | 19432809 | CX3CL1/fractalkine shedding by human hepatic stellate cells: contribution to chronic inflammation in the liver. | J Cell Mol Med | 2009 Aug |
1 |
| 40 | 19679113 | Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein. | Brain Res | 2009 Nov 3 |
1 |
| 41 | 19715556 | Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10. | Biochem J | 2009 Oct 23 |
1 |
| 42 | 19783906 | Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells. | Cancer Biol Ther | 2009 Nov |
11 |
| 43 | 19826051 | Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. | Cancer Res | 2009 Oct 15 |
2 |
| 44 | 20015014 | Fluorescent substrates useful as high-throughput screening tools for ADAM9. | Comb Chem High Throughput Screen | 2010 May |
1 |
| 45 | 20064929 | P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells. | J Biol Chem | 2010 Mar 5 |
1 |
| 46 | 20100836 | An arginine stretch limits ADAM10 exit from the endoplasmic reticulum. | J Biol Chem | 2010 Apr 2 |
2 |
| 47 | 20197648 | Improved synthesis of ADAM10 inhibitor GI254023X. | Neurodegener Dis | 2010 |
2 |
| 48 | 20413873 | Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis. | J Alzheimers Dis | 2010 |
3 |
| 49 | 20530572 | Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth. | J Cell Sci | 2010 Jul 1 |
1 |
| 50 | 20595051 | Cryptotanshinione upregulates alpha-secretase by activation PI3K pathway in cortical neurons. | Brain Res | 2010 Aug 12 |
5 |