| 1 | 1899909 | The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. | Mol Cell Biol | 1991 Mar |
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| 2 | 8576107 | Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein. | J Biol Chem | 1996 Jan 19 |
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| 3 | 9330640 | Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts. | Somat Cell Mol Genet | 1997 Mar |
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| 4 | 9560326 | Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by ins(1,3,4, 5)P4: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor. | Biochem J | 1998 May 1 |
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| 5 | 9636174 | Mitogenic and oncogenic properties of the small G protein Rap1b. | Proc Natl Acad Sci U S A | 1998 Jun 23 |
3 |
| 6 | 9950684 | The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum. | Mol Biol Cell | 1999 Feb |
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| 7 | 10022812 | Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation. | Oncogene | 1999 Feb 11 |
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| 8 | 11069064 | Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection. | Eur J Immunol | 2000 Oct |
3 |
| 9 | 11124936 | Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion. | J Biol Chem | 2001 Mar 30 |
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| 10 | 11278453 | Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia. | J Biol Chem | 2001 Apr 13 |
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| 11 | 11340161 | Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1. | Mol Cell Biol | 2001 Jun |
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| 12 | 11866427 | The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1. | Biochem Biophys Res Commun | 2002 Mar 8 |
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| 13 | 11970953 | Activation of Rap1B by G(i) family members in platelets. | J Biol Chem | 2002 Jun 28 |
4 |
| 14 | 12464615 | Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells. | J Biol Chem | 2003 Feb 7 |
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| 15 | 12873387 | Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. | Neuron | 2003 Jul 17 |
2 |
| 16 | 12887090 | CAMP activates Rap1 in differentiating mouse male germ cells: a new signaling pathway mediated by the cAMP-activated exchange factor Epac? | Cell Mol Biol (Noisy-le-grand) | 2003 May |
9 |
| 17 | 12902333 | The expression of the thyroid-stimulating hormone (TSH) receptor and the cAMP-dependent protein kinase RII beta regulatory subunit confers TSH-cAMP-dependent growth to mouse fibroblasts. | J Biol Chem | 2003 Oct 17 |
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| 18 | 14506838 | Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. | Lipids | 2003 Jul |
4 |
| 19 | 14597235 | Depolarization-induced signaling to Ras, Rap1 and MAPKs in cortical neurons. | Brain Res Mol Brain Res | 2003 Nov 6 |
2 |
| 20 | 14695209 | Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. | Cancer Res | 2003 Dec 15 |
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| 21 | 14699953 | Trafficking the NGF signal: implications for normal and degenerating neurons. | Prog Brain Res | 2004 |
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| 22 | 14701796 | The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes. | J Biol Chem | 2004 Mar 26 |
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| 23 | 15312909 | Effects of ras and Rap1 on electrical excitability of differentiated NG108-15 cells. | Neuroscience | 2004 |
2 |
| 24 | 15596148 | BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells. | Biochem Biophys Res Commun | 2005 Jan 21 |
2 |
| 25 | 15657046 | Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. | J Biol Chem | 2005 Mar 25 |
2 |
| 26 | 15894621 | Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. | Proc Natl Acad Sci U S A | 2005 May 24 |
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| 27 | 15931667 | Epac1-mediated Rap1 activation is not required for the production of nitric oxide in BV2, murine microglial cells. | J Neurosci Res | 2005 Jul 1 |
3 |
| 28 | 16116203 | Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. | J Immunol | 2005 Sep 1 |
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| 29 | 16380154 | Analyzing the mechanism of Rap1 activation in platelets: Rap1 activation is related to the release reaction mediated through the collagen receptor GPVI. | Thromb Res | 2006 |
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| 30 | 16501031 | Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis. | Mol Pharmacol | 2006 May |
3 |
| 31 | 16675582 | Bisphosphonates inhibit the growth of mesothelioma cells in vitro and in vivo. | Clin Cancer Res | 2006 May 1 |
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| 32 | 16740968 | Involvement of protein kinase C alpha (PKC alpha) in the early action of angiotensin II type 2 (AT2) effects on neurite outgrowth in NG108-15 cells: AT2-receptor inhibits PKC alpha and p21ras activity. | Endocrinology | 2006 Sep |
2 |
| 33 | 16914720 | Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. | Mol Cell Biol | 2006 Sep |
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| 34 | 16972264 | Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells. | J Cell Physiol | 2006 Dec |
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| 35 | 16998532 | Role of the Go/i signaling network in the regulation of neurite outgrowth. | Can J Physiol Pharmacol | 2006 Jul |
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| 36 | 17077580 | Evidence for existence of cAMP-Epac signaling in the heads of mouse epididymal spermatozoa. | J Reprod Dev | 2007 Feb |
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| 37 | 17532477 | Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-kappaB pathway in Raw 264.7 murine macrophages. | Immunol Lett | 2007 Jun 15 |
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| 38 | 17538012 | The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. | Mol Biol Cell | 2007 Aug |
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| 39 | 17890448 | Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. | Blood | 2008 Jan 15 |
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| 40 | 17971444 | Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology. | J Biol Chem | 2007 Dec 28 |
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| 41 | 18040047 | Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. | Proc Natl Acad Sci U S A | 2007 Dec 4 |
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| 42 | 18056377 | Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. | J Immunol | 2007 Dec 15 |
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| 43 | 18172297 | Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester. | Cancer Res | 2008 Jan 1 |
4 |
| 44 | 18305243 | Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. | J Neurosci | 2008 Feb 27 |
2 |
| 45 | 18319399 | A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. | Blood | 2008 May 1 |
2 |
| 46 | 18577515 | Rap1 activation plays a regulatory role in pancreatic amylase secretion. | J Biol Chem | 2008 Aug 29 |
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| 47 | 18805968 | Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis. | Blood | 2009 Jan 8 |
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| 48 | 19167486 | B cell receptor-induced growth arrest and apoptosis in WEHI-231 immature B lymphoma cells involve cyclic AMP and Epac proteins. | Cell Signal | 2009 Apr |
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| 49 | 19170062 | Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function. | J Cell Physiol | 2009 Jun |
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| 50 | 19538282 | Mechanisms of outside-in signaling at the tight junction by junctional adhesion molecule A. | Ann N Y Acad Sci | 2009 May |
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