FKBP prolyl isomerase 1A ; Rattus norvegicus






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1 1380976 The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. J Exp Med 1992 Sep 1 5
2 7539960 Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell. Transplantation 1995 Jun 15 1
3 7822316 Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 1995 Jan 13 1
4 8623162 Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities. Transplantation 1996 Mar 27 1
5 8917502 A three-hybrid system for detecting small ligand-protein receptor interactions. Proc Natl Acad Sci U S A 1996 Nov 12 1
6 9344552 A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration. Exp Neurol 1997 Oct 2
7 9457703 FK506 and the role of immunophilins in nerve regeneration. Mol Neurobiol 1997 Dec 3
8 9555045 Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycin. Brain Res 1998 Mar 9 1
9 9653668 The plasma FK506-binding protein 12 level is related to acute cellular rejection in small bowel transplantation. Immunopharmacol Immunotoxicol 1998 May 2
10 9852316 Effects of ivermectin and midecamycin on ryanodine receptors and the Ca2+-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle. J Physiol 1999 Jan 15 1
11 9918571 Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury. J Pharmacol Exp Ther 1999 Feb 3
12 10566134 [Stimulation of Schwann cell growth and axon regeneration of peripheral nerves by the immunosuppressive drug FK 506]. Handchir Mikrochir Plast Chir 1999 Sep 1
13 10752948 The effects of FK506 on retinal ganglion cells after optic nerve crush. Invest Ophthalmol Vis Sci 2000 Apr 2
14 11041285 Co-administration of furosemide augments tacrolimus-induced impairment in kidney function in rats. Ren Fail 2000 2
15 11113532 Postischemic changes in the immunophilin FKBP12 in the rat brain. Brain Res Mol Brain Res 2000 Dec 8 1
16 11208908 ortho-substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. J Neurochem 2001 Jan 2
17 11359520 Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci 2001 May 2
18 11772413 Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12. Biochem J 2002 Jan 15 2
19 12183690 Genetically engineered analogs of ascomycin for nerve regeneration. J Pharmacol Exp Ther 2002 Sep 11
20 12494287 FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury. Int J Impot Res 2002 Dec 3
21 12671210 Stimulation of Schwann cell proliferation and axonal regeneration by FK 506. Restor Neurol Neurosci 2000 1
22 12871169 Immunophilins in nervous system degeneration and regeneration. Curr Top Med Chem 2003 2
23 12927209 Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain. Neuroscience 2003 2
24 15780950 Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17/2.8 cells. Bone 2005 Feb 8
25 15994335 Activation of M1 muscarinic acetylcholine receptors stimulates the formation of a multiprotein complex centered on TRPC6 channels. J Biol Chem 2005 Sep 9 4
26 16547004 The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. J Biol Chem 2006 May 26 3
27 17877381 Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins. J Proteome Res 2007 Oct 4
28 18570278 Decreased FKBP12.6 expression and enhanced endothelin receptor signaling associated with arrhymogenesis in myocardial infarction rats. Phytother Res 2008 Aug 1
29 18577426 Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: heat shock protein 70 levels are modulated in microglial cells. Neuroscience 2008 Jul 31 1
30 18635947 FKBP family proteins: immunophilins with versatile biological functions. Neurosignals 2008 1
31 19234362 FKBP12 depletion leads to loss of sarcoplasmic reticulum Ca(2+) stores in rat vas deferens. J Pharmacol Sci 2009 Feb 3
32 21255728 FKBP12 binds to acylated H-ras and promotes depalmitoylation. Mol Cell 2011 Jan 21 3
33 21293474 Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein. Acta Pharmacol Sin 2011 Feb 1
34 23867624 FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest 2013 Aug 6
35 24291098 FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? Eur J Pharmacol 2014 Sep 15 1
36 29229832 FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome. Proc Natl Acad Sci U S A 2017 Dec 26 2
37 30476735 Downregulation of TRPC6 expression is a critical molecular event during FK506 treatment for overactive bladder. Cell Calcium 2019 Jan 1
38 30999619 FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis. Int J Mol Sci 2019 Apr 17 1
39 31152486 Inhibition of the mTOR pathway: A new mechanism of β cell toxicity induced by tacrolimus. Am J Transplant 2019 Dec 9
40 31468006 A Mechanism for Statin-Induced Susceptibility to Myopathy. JACC Basic Transl Sci 2019 Aug 4
41 31916935 Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification. Elife 2020 Jan 9 1
42 33502189 Phosphoproteomic Analysis and Protein-Protein Interaction of Rat Aorta GJA1 and Rat Heart FKBP1A after Secoiridoid Consumption from Virgin Olive Oil: A Functional Proteomic Approach. J Agric Food Chem 2021 Feb 10 1