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| 2 | 10529789 | New perspectives on the molecular basis of hereditary bone tumours. | Mol Med Today | 1999 Nov |
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| 3 | 10545594 | A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses. | Hum Mol Genet | 1999 Nov |
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| 4 | 10639137 | The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. | Proc Natl Acad Sci U S A | 2000 Jan 18 |
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| 5 | 11121397 | rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. | J Biol Chem | 2001 Feb 16 |
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| 6 | 11170095 | Mutation frequencies of EXT1 and EXT2 in 43 Japanese families with hereditary multiple exostoses. | Am J Med Genet | 2001 Feb 15 |
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| 7 | 11390981 | Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis. | Proc Natl Acad Sci U S A | 2001 Jun 19 |
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| 8 | 11391482 | Etiological point mutations in the hereditary multiple exostoses gene EXT1: a functional analysis of heparan sulfate polymerase activity. | Am J Hum Genet | 2001 Jul |
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| 9 | 11432960 | Genotype-phenotype correlation in hereditary multiple exostoses. | J Med Genet | 2001 Jul |
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| 10 | 11461073 | A novel deletion mutation of the EXT2 gene in a large Chinese pedigree with hereditary multiple exostosis. | Br J Cancer | 2001 Jul 20 |
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| 11 | 12032595 | Association of autism in two patients with hereditary multiple exostoses caused by novel deletion mutations of EXT1. | J Hum Genet | 2002 |
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| 12 | 12110435 | Heparan sulfate abnormalities in exostosis growth plates. | Bone | 2002 Jul |
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| 13 | 12417417 | Hereditary multiple exostoses and heparan sulfate polymerization. | Biochim Biophys Acta | 2002 Dec 19 |
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| 14 | 12796152 | Exercise training improves exertional dyspnea in patients with COPD: evidence of the role of mechanical factors. | Chest | 2003 Jun |
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| 15 | 12907685 | In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction. | J Biol Chem | 2003 Oct 24 |
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| 16 | 14605369 | Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. | Science | 2003 Nov 7 |
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| 17 | 15177029 | Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. | Dev Cell | 2004 Jun |
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| 18 | 15372456 | Genome-wide profiling of oral squamous cell carcinoma. | J Pathol | 2004 Nov |
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| 19 | 15385438 | Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells. | Hum Mol Genet | 2004 Nov 15 |
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| 20 | 15985493 | A novel EXT1 splice site mutation in a kindred with hereditary multiple exostosis and osteoporosis. | J Clin Endocrinol Metab | 2005 Sep |
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| 21 | 16026543 | Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes. | Differentiation | 2005 Jun |
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| 22 | 16283885 | An optimized DHPLC protocol for molecular testing of the EXT1 and EXT2 genes in hereditary multiple osteochondromas. | Clin Genet | 2005 Dec |
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| 23 | 16622899 | EXT-related pathways are not involved in the pathogenesis of dysplasia epiphysealis hemimelica and metachondromatosis. | J Pathol | 2006 Jul |
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| 24 | 17237233 | Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. | J Biol Chem | 2007 Mar 16 |
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| 25 | 17301954 | A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients. | Genes Chromosomes Cancer | 2007 May |
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| 26 | 17442818 | Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. | J Neurosci | 2007 Apr 18 |
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| 27 | 17610078 | Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homolog tout velu. | Dev Genes Evol | 2007 Aug |
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| 28 | 17761672 | Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation. | J Biol Chem | 2007 Nov 9 |
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| 29 | 18216313 | Familial nephropathy and multiple exostoses with exostosin-1 (EXT1) gene mutation. | J Am Soc Nephrol | 2008 Mar |
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| 30 | 18337501 | Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation. | Proc Natl Acad Sci U S A | 2008 Mar 25 |
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| 31 | 18626493 | Glomerular filtration: the charge debate charges ahead. | Kidney Int | 2008 Aug |
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| 32 | 18955118 | Functional interrelations between nucleus raphé dorsalis and nucleus raphé medianus: a dual probe microdialysis study of glutamate-stimulated serotonin release. | Brain Res Bull | 2009 Mar 16 |
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| 33 | 19839753 | Identification of four novel EXT1 and EXT2 mutations in five Chinese pedigrees with hereditary multiple exostoses. | Genet Test Mol Biomarkers | 2009 Dec |
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| 34 | 19965677 | Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma. | Blood | 2010 Jan 21 |
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| 35 | 20233912 | Rufinamide: a new antiepileptic medication for the treatment of seizures associated with lennox-gastaut syndrome. | Ann Pharmacother | 2010 Apr |
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| 36 | 20377530 | Biosynthesis of heparan sulfate in EXT1-deficient cells. | Biochem J | 2010 May 27 |
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| 37 | 20387539 | [Exploration of the molecular mechanism of ocular development and the creation of animal models for ocular diseases]. | Nippon Ganka Gakkai Zasshi | 2010 Mar |
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| 38 | 20566323 | Structural identification of recombinant human CD83 mutant variant as a potent therapeutic protein. | Protein Expr Purif | 2010 Oct |
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| 39 | 20807644 | Roles of heparan sulfate in mammalian brain development current views based on the findings from Ext1 conditional knockout studies. | Prog Mol Biol Transl Sci | 2010 |
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| 40 | 20813973 | No haploinsufficiency but loss of heterozygosity for EXT in multiple osteochondromas. | Am J Pathol | 2010 Oct |
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| 41 | 20872591 | A splice-site mutation leads to haploinsufficiency of EXT2 mRNA for a dominant trait in a large family with multiple osteochondromas. | J Orthop Res | 2010 Nov |
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| 42 | 21280143 | Tiling resolution array-CGH shows that somatic mosaic deletion of the EXT gene is causative in EXT gene mutation negative multiple osteochondromas patients. | Hum Mutat | 2011 Feb |
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| 43 | 21586278 | Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. | Dev Biol | 2011 Jul 15 |
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| 44 | 21703028 | Breakpoint characterization of large deletions in EXT1 or EXT2 in 10 multiple osteochondromas families. | BMC Med Genet | 2011 Jun 26 |
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| 45 | 21956842 | Epiphyseal growth plate and secondary peripheral chondrosarcoma: the neighbours matter. | J Pathol | 2012 Jan |
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| 46 | 22025563 | Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers. | Cancer Res | 2011 Dec 15 |
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| 47 | 22037484 | Identification and functional characterization of the human EXT1 promoter region. | Gene | 2012 Jan 15 |
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| 48 | 22040554 | Mutation analysis and prenatal diagnosis of EXT1 gene mutations in Chinese patients with multiple osteochondromas. | Chin Med J (Engl) | 2011 Oct |
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| 49 | 22848466 | Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids. | PLoS One | 2012 |
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| 50 | 23083943 | Effectiveness and tolerability of rufinamide in children and young adults with Lennox-Gastaut syndrome: a single center study in Korea. | Clin Neurol Neurosurg | 2013 Jul |
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