sodium channel, voltage-gated, type X, alpha ; Mus musculus






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1 9143495 Cloning and characterization of a mouse sensory neuron tetrodotoxin-resistant voltage-gated sodium channel gene, Scn10a. Genomics 1997 Apr 15 6
2 10216225 Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Brain Res Mol Brain Res 1999 Apr 20 3
3 10543423 Inhibition by steroids of [14C]-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells. Naunyn Schmiedebergs Arch Pharmacol 1999 Sep 8
4 11568640 A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain. Neuroreport 2001 Oct 8 1
5 12046980 Molecular diversity of structure and function of the voltage-gated Na+ channels. Jpn J Pharmacol 2002 Apr 2
6 12351708 Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. J Neurosci 2002 Oct 1 3
7 12824446 The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol 2003 Aug 1 1
8 15047701 Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat. J Biol Chem 2004 Jun 4 1
9 15205116 Two TTX-resistant Na+ currents in mouse colonic dorsal root ganglia neurons and their role in colitis-induced hyperexcitability. Am J Physiol Gastrointest Liver Physiol 2004 Oct 5
10 16029194 Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci 2005 Jul 2
11 16598065 Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons. J Neurophysiol 2006 Jul 4
12 16838161 Multiple types of Na(+) currents mediate action potential electrogenesis in small neurons of mouse dorsal root ganglia. Pflugers Arch 2006 Oct 1
13 16839522 The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res 2006 Aug 23 3
14 16850455 Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia. Genesis 2006 Aug 2
15 17005919 Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels. J Pharmacol Exp Ther 2007 Jan 9
16 18272876 Properties of wild-type and fluorescent protein-tagged mouse tetrodotoxin-resistant sodium channel (Na V 1.8) heterologously expressed in rat sympathetic neurons. J Neurophysiol 2008 Apr 4
17 18399542 Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina. J Comp Neurol 2008 Jun 20 4
18 18845912 Involvement of voltage-gated sodium channel Na(v)1.8 in the regulation of the release and synthesis of substance P in adult mouse dorsal root ganglion neurons. J Pharmacol Sci 2008 Oct 2
19 19239624 Trinitrobenzenesulphonic acid colitis alters Na 1.8 channel expression in mouse dorsal root ganglia neurons. Neurogastroenterol Motil 2009 Aug 1
20 19846698 T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. J Neurosci 2009 Oct 21 1
21 20147541 GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci 2010 Feb 10 1
22 20174994 The tetrodotoxin-resistant Na+ channel Na (v)1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors. Pflugers Arch 2010 Apr 6
23 20308253 An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors. J Physiol 2010 May 15 3
24 20411123 Regulation of the spontaneous augmentation of Na(V)1.9 in mouse dorsal root ganglion neurons: effect of PKA and PKC pathways. Mar Drugs 2010 Mar 19 1
25 20861385 Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci 2010 Sep 22 2
26 21040853 VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron 2010 Nov 4 1
27 22087007 Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A 2011 Nov 29 1
28 22172548 Menthol pain relief through cumulative inactivation of voltage-gated sodium channels. Pain 2012 Feb 3
29 22260870 Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels. Neuroscience 2012 Mar 29 1
30 22367990 A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis. Ann Neurol 2012 Feb 1
31 22371119 Alterations of gene expression of sodium channels in dorsal root ganglion neurons of estrogen receptor knockout (ERKO) mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Endocrine 2012 Aug 1
32 22703890 Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. Pain 2012 Oct 1
33 22723299 Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circ Res 2012 Jul 20 2
34 22723301 Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology. Circ Res 2012 Jul 20 1
35 23382806 Varicella-zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line. PLoS One 2013 1
36 23573123 Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia. Evid Based Complement Alternat Med 2013 2
37 23773488 Histamine modulation of acute nociception involves regulation of Nav 1.8 in primary afferent neurons in mice. CNS Neurosci Ther 2013 Sep 3
38 24032674 HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. Br J Pharmacol 2013 Nov 6
39 24069332 Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice. PLoS One 2013 1
40 24198377 KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. J Neurosci 2013 Nov 6 1
41 24875357 Chronic haloperidol increases voltage-gated Na+ currents in mouse cortical neurons. Biochem Biophys Res Commun 2014 Jul 18 5
42 24957987 Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia. Mol Pain 2014 Jun 23 1
43 25012584 Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves. Br J Anaesth 2015 Jan 1
44 25747279 Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis. PLoS One 2015 1
45 26383867 Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons. Pflugers Arch 2016 Jan 7
46 27530546 An oral NaV1.8 blocker improves motor function in mice completely deficient of myelin protein P0. Neurosci Lett 2016 Oct 6 1
47 27538456 β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. Nat Commun 2016 Aug 19 1
48 27806966 Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart. J Am Heart Assoc 2016 Nov 2 2
49 28211895 Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice. Sci Rep 2017 Feb 13 1
50 28216001 Loperamide inhibits sodium channels to alleviate inflammatory hyperalgesia. Neuropharmacology 2017 May 1 1