Wnt family member 5A ; Homo sapiens






311 Article(s)
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1 7759542 Regulation of Wnt5a mRNA expression in human mammary epithelial cells by cell shape, confluence, and hepatocyte growth factor. J Biol Chem 1995 May 26 1
2 8288227 Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. Genomics 1993 Nov 3
3 9367869 Expression of Wnt5a is downregulated by extracellular matrix and mutated c-Ha-ras in the human mammary epithelial cell line MCF-10A. Biochem Biophys Res Commun 1997 Oct 29 2
4 9716023 Regulation of Wnt5a expression in human mammary cells by protein kinase C activity and the cytoskeleton. Br J Cancer 1998 Aug 3
5 11809689 Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res 2002 Jan 15 1
6 12165812 Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells. Int J Mol Med 2002 Sep 2
7 12244165 Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway. J Immunol 2002 Oct 1 1
8 12471617 Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion. Int J Cancer 2003 Jan 20 2
9 14610063 Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. J Cell Biol 2003 Nov 10 1
10 14766423 The WNT/calcium pathway: biochemical mediators, tools and future requirements. Front Biosci 2004 Jan 1 1
11 15531600 Intervention in context-sensitive probabilistic Boolean networks. Bioinformatics 2005 Apr 1 1
12 15592517 Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. Oncogene 2005 Feb 10 2
13 15659394 Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. J Biol Chem 2005 Mar 25 7
14 15925444 Wnt-5a gene expression in malignant human neuroblasts. Cancer Lett 2005 Oct 18 3
15 16029874 Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environ Res 2006 Jan 1
16 16282442 Transcriptional profiling of mammary gland side population cells. Stem Cells 2006 Apr 2
17 16330545 A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J Biol Chem 2006 Feb 3 3
18 16391828 Alteration of gene expression in response to bone morphogenetic protein-2 in androgen-dependent human prostate cancer LNCaP cells. Int J Mol Med 2006 Feb 1
19 16880514 Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. Mol Cell Biol 2006 Aug 3
20 16920709 Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway. J Biol Chem 2006 Oct 13 2
21 17101698 Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration. J Cell Biol 2006 Nov 20 1
22 17117926 Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J 2007 Mar 15 2
23 17426020 The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem 2007 Jun 8 1
24 17463182 Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. Am J Physiol Gastrointest Liver Physiol 2007 Jul 4
25 17486081 Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer. Oncogene 2007 Oct 4 1
26 17986005 Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 2007 Nov 3
27 18032022 WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia. Eur J Cancer 2007 Dec 2
28 18407462 Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways. Cell Signal 2008 Jul 7
29 18615587 Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase. J Cell Biochem 2008 Oct 1 1
30 18708054 Wnt4 and Wnt5a promote adipocyte differentiation. FEBS Lett 2008 Sep 22 1
31 18832445 The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway. Am J Physiol Gastrointest Liver Physiol 2008 Dec 4
32 18929644 Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell Signal 2009 Jan 1
33 19061910 Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation. Toxicol Appl Pharmacol 2009 Feb 15 2
34 19063862 Amino acid limitation induces down-regulation of WNT5a at transcriptional level. Biochem Biophys Res Commun 2009 Jan 23 1
35 19099253 Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma. Methods Mol Biol 2008 1
36 19148501 Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer. Oncol Rep 2009 Feb 1
37 19177143 Wnt5A activates the calpain-mediated cleavage of filamin A. J Invest Dermatol 2009 Jul 2
38 19237581 Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. Proc Natl Acad Sci U S A 2009 Mar 10 1
39 19244247 Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells. J Biol Chem 2009 Apr 17 3
40 19420254 Wnt5a induces simultaneous cortical axon outgrowth and repulsive axon guidance through distinct signaling mechanisms. J Neurosci 2009 May 6 2
41 19447629 Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity. Bioorg Med Chem 2009 Jul 1 2
42 19470740 Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res 2009 Jun 15 1
43 19651774 Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner. J Biol Chem 2009 Oct 2 6
44 19696445 Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells. J Biol Chem 2009 Oct 16 1
45 19874313 Epigenetic regulation of the non-canonical Wnt pathway in acute myeloid leukemia. Cancer Sci 2010 Feb 2
46 19878652 WNT5A inhibits human dental papilla cell proliferation and migration. Biochem Biophys Res Commun 2009 Dec 18 3
47 19901340 A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci U S A 2009 Nov 17 4
48 19918918 WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev Dyn 2010 Jan 1
49 19946729 cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. Cell Mol Life Sci 2010 Mar 2
50 20032469 Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes. J Biol Chem 2010 Feb 26 1