| 1 | 9836640 | Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. | Science | 1998 Dec 4 |
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| 2 | 10435585 | Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. | Oncogene | 1999 Jul 15 |
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| 3 | 10531013 | Caffeine inhibits the checkpoint kinase ATM. | Curr Biol | 1999 Oct 7 |
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| 4 | 10673500 | Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. | Genes Dev | 2000 Feb 1 |
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| 5 | 10673501 | The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. | Genes Dev | 2000 Feb 1 |
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| 6 | 10713094 | Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase. | J Biol Chem | 2000 Mar 17 |
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| 7 | 10724175 | hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. | Nature | 2000 Mar 9 |
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| 8 | 10744722 | Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. | J Biol Chem | 2000 Apr 7 |
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| 9 | 10801407 | How to activate p53. | Curr Biol | 2000 Apr 20 |
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| 10 | 10809772 | Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells. | J Biol Chem | 2000 May 19 |
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| 11 | 10973490 | Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. | Proc Natl Acad Sci U S A | 2000 Sep 12 |
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| 12 | 11007451 | Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells. | Cell Growth Differ | 2000 Sep |
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| 13 | 11053450 | Characterization of tumor-associated Chk2 mutations. | J Biol Chem | 2001 Jan 26 |
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| 14 | 11085506 | Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. | Cancer Res | 2000 Nov 1 |
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| 15 | 11096068 | The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. | J Biol Chem | 2001 Feb 16 |
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| 16 | 11278522 | Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase. | J Biol Chem | 2001 Apr 27 |
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| 17 | 11279124 | Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. | J Biol Chem | 2001 May 25 |
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| 18 | 11298456 | The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. | Nature | 2001 Apr 12 |
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| 19 | 11326311 | Cisplatinum and taxol induce different patterns of p53 phosphorylation. | Neoplasia | 2001 Jan-Feb |
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| 20 | 11533665 | Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex. | Nat Cell Biol | 2001 Sep |
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| 21 | 11535615 | Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. | J Cell Biol | 2001 Sep 3 |
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| 22 | 11557032 | Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells. | FEBS Lett | 2001 Sep 7 |
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| 23 | 11668173 | Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. | J Biol Chem | 2001 Dec 21 |
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| 24 | 11719428 | Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome. | Cancer Res | 2001 Nov 15 |
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| 25 | 11741320 | Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR. | Biochem Biophys Res Commun | 2001 Dec 21 |
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| 26 | 11864911 | Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. | Cell Growth Differ | 2002 Feb |
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| 27 | 11901158 | Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain. | J Biol Chem | 2002 May 31 |
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| 28 | 12049740 | Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. | Mol Cell | 2002 May |
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| 29 | 12150968 | Chk1 signaling pathways that mediated G(2)M checkpoint in relation to the cellular resistance to the novel topoisomerase I poison BNP1350. | Biochem Biophys Res Commun | 2002 Jul 12 |
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| 30 | 12363465 | Analysis of CHK2 in patients with myelodysplastic syndromes. | Leuk Res | 2002 Nov |
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| 31 | 12384533 | UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. | Cancer Res | 2002 Oct 15 |
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| 32 | 12386164 | Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation. | J Biol Chem | 2002 Dec 13 |
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| 33 | 12447382 | 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. | Nat Cell Biol | 2002 Dec |
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| 34 | 12493754 | Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. | J Biol Chem | 2003 Mar 7 |
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| 35 | 12499368 | DNA-dependent acetylation of p53 by the transcription coactivator p300. | J Biol Chem | 2003 Apr 11 |
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| 36 | 12607004 | MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. | Nature | 2003 Feb 27 |
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| 37 | 12637545 | Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. | J Biol Chem | 2003 May 16 |
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| 38 | 12654916 | Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. | J Biol Chem | 2003 Jun 6 |
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| 39 | 12676583 | Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. | Cancer Cell | 2003 Mar |
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| 40 | 12711320 | Determination of substrate specificity and putative substrates of Chk2 kinase. | Biochem Biophys Res Commun | 2003 May 2 |
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| 41 | 12717439 | Chk2 activates E2F-1 in response to DNA damage. | Nat Cell Biol | 2003 May |
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| 42 | 12759351 | Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. | J Biol Chem | 2003 Aug 8 |
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| 43 | 12805407 | Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. | Mol Cancer Res | 2003 Jun |
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| 44 | 12810724 | The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. | J Biol Chem | 2003 Aug 29 |
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| 45 | 12855706 | Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. | J Biol Chem | 2003 Sep 19 |
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| 46 | 12897801 | Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. | EMBO Rep | 2003 Aug |
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| 47 | 14507240 | BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India. | Asian Pac J Cancer Prev | 2003 Jul-Sep |
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| 48 | 14701743 | Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. | Mol Cell Biol | 2004 Jan |
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| 49 | 14726672 | Fibronectin alters cell survival and intracellular signaling of confluent A549 cultures after irradiation. | Cancer Biol Ther | 2004 Jan |
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| 50 | 14757171 | Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1. | Biochem Pharmacol | 2004 Feb 15 |
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