glutathione peroxidase 1 ; Homo sapiens






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1 1426231 The 5' untranslated region of the human cellular glutathione peroxidase gene is indispensable for its expression in COS-7 cells. FEBS Lett 1992 Nov 2 3
2 1556108 Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1). J Biol Chem 1992 Mar 25 3
3 1964932 Oxygen radical generation in human platelets: dependence on 12-lipoxygenase activity and on the glutathione cycle. Int Arch Allergy Appl Immunol 1990 3
4 2158080 Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfectants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7 cells. Nucleic Acids Res 1990 Mar 25 8
5 2804377 Post-transcriptional regulation of glutathione peroxidase gene expression by selenium in the HL-60 human myeloid cell line. Blood 1989 Nov 15 1
6 7489513 Structure and function of the selenium translation element in the 3'-untranslated region of human cellular glutathione peroxidase mRNA. RNA 1995 Jul 1
7 7684384 Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. J Biol Chem 1993 May 25 3
8 7829093 An in-frame trinucleotide repeat in the coding region of the human cellular glutathione peroxidase (GPX1) gene: in vivo polymorphism and in vitro instability. Genomics 1994 Sep 1 4
9 8001233 Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer. Carcinogenesis 1994 Dec 7
10 8135533 Extracellular glutathione peroxidase mRNA and protein in human cell lines. Arch Biochem Biophys 1994 Mar 2
11 8239661 Reactivity of plasma glutathione peroxidase with hydroperoxide substrates and glutathione. Arch Biochem Biophys 1993 Nov 15 8
12 8428933 Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. J Biol Chem 1993 Feb 5 6
13 8530473 RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA. J Biol Chem 1995 Dec 22 1
14 8597083 Glutathione peroxidase and oxidative stress. Toxicol Lett 1995 Dec 6
15 8761945 Selenium-regulated translation control of heterologous gene expression: normal function of selenocysteine-substituted gene products. J Cell Biochem 1996 Jun 1 1
16 8824885 Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum Mol Genet 1996 Feb 3
17 8886791 Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Free Radic Biol Med 1996 1
18 9315309 RNA and protein requirements for eukaryotic selenoprotein synthesis. Biomed Environ Sci 1997 Sep 1
19 9488664 Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B. J Biol Chem 1998 Mar 6 3
20 9535791 Selenoproteins are expressed in fetal human osteoblast-like cells. Biochem Biophys Res Commun 1998 Apr 7 3
21 9566912 Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol Cell Biol 1998 May 10
22 9792801 Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem Biophys Res Commun 1998 Oct 20 1
23 10220143 Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1. Hum Mutat 1999 1
24 10455235 Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant. Yeast 1999 Aug 3
25 10657953 The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer. Carcinogenesis 2000 Feb 2
26 10833429 Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells. Biochem Biophys Res Commun 2000 Jun 7 4
27 10874123 Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines. Biochem Pharmacol 2000 Aug 15 1
28 10880344 Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells. Biochem J 2000 Jul 15 2
29 10882192 Regulation of cyclooxygenase and 12-lipoxygenase catalysis by phospholipid hydroperoxide glutathione peroxidase in A431 cells. Prostaglandins Leukot Essent Fatty Acids 2000 Apr 1
30 11103801 Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. Cancer Res 2000 Nov 15 3
31 11112379 Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1. Blood Cells Mol Dis 2000 Oct 2
32 11115402 Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. Biochem J 2001 Jan 1 4
33 11398312 [Nutritional consideration for changes in dietary habit and health promotion practices in community health care; from the view point of selenium]. Nihon Koshu Eisei Zasshi 2001 Apr 2
34 11491654 GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex. Antioxid Redox Signal 2001 Jun 5
35 11502879 Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells. Mol Pharmacol 2001 Sep 17
36 11568438 Evidence that selenium deficiency results in the cytoplasmic decay of GPx1 mRNA dependent on pre-mRNA splicing proteins bound to the mRNA exon-exon junction. Biofactors 2001 1
37 11568460 Modulation of steroidogenesis by selenium in a novel adrenal cell line developed using targeted tumorigenesis. Biofactors 2001 1
38 11672444 Comparative impacts of glutathione peroxidase-1 gene knockout on oxidative stress induced by reactive oxygen and nitrogen species in mouse hepatocytes. Biochem J 2001 Nov 1 4
39 11776067 Effect of selenium on human myocardial glutathione peroxidase gene expression. Chin Med J (Engl) 2000 Sep 3
40 11818388 Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2. Invest Ophthalmol Vis Sci 2002 Feb 5
41 12221075 Glutathione peroxidase-1 protects from CD95-induced apoptosis. J Biol Chem 2002 Nov 8 2
42 12226550 Expressional changes of the vascular antioxidant system in atherosclerotic coronary arteries. J Atheroscler Thromb 2002 1
43 12398936 Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrest. Free Radic Biol Med 2002 Nov 1 3
44 12429743 Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. J Biol Chem 2003 Jan 17 1
45 12496980 Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer. Prostate Cancer Prostatic Dis 2002 4
46 12530527 Differential influences of various arsenic compounds on glutathione redox status and antioxidative enzymes in porcine endothelial cells. Cell Mol Life Sci 2002 Nov 3
47 12810669 Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer Res 2003 Jun 15 7
48 12829378 Overexpression of cytosolic glutathione peroxidase (GPX1) delays endothelial cell growth and increases resistance to toxic challenges. Biochimie 2003 Jun 7
49 12867715 Tissue distribution, molecular cloning, and gene expression of cytosolic glutathione peroxidase in Japanese monkey. Zoolog Sci 2003 Jul 1
50 12893824 Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem 2003 Oct 10 6