Loratadine






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1 1283698 Agonist-antagonist interactions in the skin: comparison of effects of loratadine and cetirizine on skin vascular responses to prick tests with histamine and substance P. J Dermatol Sci 1992 Nov 1
2 1357858 Effects of antihistamines on cutaneous reactions and influx of eosinophils after local injection of PAF, kallikrein, compound 48/80 and histamine in patients with chronic urticaria and healthy subjects. Acta Derm Venereol 1992 1
3 1534660 Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice. Biochem Pharmacol 1992 May 28 2
4 1967919 Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria. Ann Allergy 1990 Feb 1
5 1977506 Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy 1990 Aug 1
6 2523301 Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs 1989 Jan 1
7 2568212 Nonsedating histamine H1-receptor antagonists. Clin Pharm 1989 May 1
8 7510965 In vitro inhibition, by loratadine and descarboxyethoxyloratadine, of histamine release from human basophils, and of histamine release and intracellular calcium fluxes in rat basophilic leukemia cells (RBL-2H3). Biochem Pharmacol 1994 Mar 2 6
9 7542675 Loratadine reduces allergen-induced mucosal output of alpha 2-macroglobulin and tryptase in allergic rhinitis. J Allergy Clin Immunol 1995 Jul 4
10 7581058 [Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction]. Pneumonol Alergol Pol 1995 1
11 7677235 Inhibitory activity of loratadine and descarboethoxyloratadine on expression of ICAM-1 and HLA-DR by nasal epithelial cells. Allergy 1995 Mar 1
12 8281352 The effect of loratadine on activated cells of the nasal mucosa in patients with allergic rhinitis. J Investig Allergol Clin Immunol 1993 Jul-Aug 3
13 8615885 Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6. Biochem Pharmacol 1996 Jan 26 9
14 9179431 Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. Clin Exp Allergy 1997 May 8
15 9271355 Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart. Mol Pharmacol 1997 Aug 5
16 9349397 Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels. Cardiovasc Res 1997 Aug 4
17 9360756 Reduction of soluble ICAM-1 levels in nasal secretion by H1-blockers in seasonal allergic rhinitis. Allergy 1997 Oct 2
18 9383258 Loratadine treatment of rhinitis due to pollen allergy reduces epithelial ICAM-1 expression. Clin Exp Allergy 1997 Oct 5
19 9384491 Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5. Br J Pharmacol 1997 Nov 1
20 9618706 [Histamine in the pathogenesis of asthma]. Nihon Yakurigaku Zasshi 1998 Apr 1
21 9636821 Loratadine reduces the expression of ICAM-1. Allergy 1998 May 1
22 9658196 Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines. Mol Pharmacol 1998 Jul 1
23 10101740 Inhibitory effect of loratadine on leukotriene B4 production by neutrophils either alone or during interaction with human airway epithelial cells. Pulm Pharmacol Ther 1998 2
24 10400845 Effect of loratadine on nitrogen dioxide-induced changes in electrical resistance and release of inflammatory mediators from cultured human bronchial epithelial cells. J Allergy Clin Immunol 1999 Jul 1
25 10563471 Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes. Inflamm Res 1999 Oct 1
26 10597864 Blockade of cardiac potassium and other channels by antihistamines. Drug Saf 1999 1
27 10597902 In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines. Chem Biol Interact 1999 Nov 15 8
28 10604956 Loratadine blockade of K(+) channels in human heart: comparison with terfenadine under physiological conditions. J Pharmacol Exp Ther 2000 Jan 1
29 10633171 Constitutive activity of the histamine H(1) receptor reveals inverse agonism of histamine H(1) receptor antagonists. Eur J Pharmacol 2000 Jan 3 2
30 10772385 Inhibition of cytokine secretion from human leukemic mast cells and basophils by H1- and H2-receptor antagonists. Exp Dermatol 2000 Apr 1
31 10800633 Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 1st communication: receptor selectivity, antihistaminic activity, and antiallergenic effects. Arzneimittelforschung 2000 Apr 3
32 10858871 Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 2nd communication: lack of central nervous system and cardiovascular effects. Arzneimittelforschung 2000 May 2
33 10959557 In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res 2000 Jul 2
34 11179434 Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol 2001 Mar 1
35 11240972 Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation. Clin Pharmacol Ther 2001 Mar 2
36 11432448 Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. Life Sci 2001 May 11 1
37 11454724 Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein. Drug Metab Dispos 2001 Aug 2
38 11496238 Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells. J Allergy Clin Immunol 2001 Aug 5
39 11502723 In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos 2001 Sep 5
40 11505807 Antihistamines and serum adhesion molecule levels. Allerg Immunol (Paris) 2001 Jun 2
41 11763722 Effect of specific immunotherapy versus loratadine on serum adhesion molecules. Allerg Immunol (Paris) 2001 Oct 2
42 12062662 LC determination of loratadine and related impurities. J Pharm Biomed Anal 2002 Jun 20 1
43 12584158 P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos 2003 Mar 1
44 12768222 Desloratadine: A preclinical and clinical overview. Drugs Today (Barc) 2001 Apr 1
45 12789223 Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled cohort study. J Allergy Clin Immunol 2003 Jun 1
46 12962522 Desloratadine: an update of its efficacy in the management of allergic disorders. Drugs 2003 1
47 14520518 Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin. Inflamm Res 2003 Oct 1
48 14681337 Human liver aldehyde oxidase: inhibition by 239 drugs. J Clin Pharmacol 2004 Jan 1
49 15932952 Effect of cyp2d6*10 allele on the pharmacokinetics of loratadine in chinese subjects. Drug Metab Dispos 2005 Sep 8
50 16076650 Circadian time-dependent differences in murine tolerance to the antihistaminic agent loratadine. Chronobiol Int 2005 1