selexipag






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1 17545310 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J Pharmacol Exp Ther 2007 Sep 1
2 20660124 Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function. J Pharmacol Exp Ther 2010 Oct 3
3 22362844 Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J 2012 Oct 1
4 22918043 Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery. J Pharmacol Exp Ther 2012 Dec 1
5 24392948 Selexipag for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother 2014 Feb 1
6 25277144 Multiple-dose up-titration study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of selexipag, an orally available selective prostacyclin receptor agonist, in healthy subjects. Pharmacology 2014 1
7 25850750 Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag. Am J Cardiovasc Drugs 2015 Jun 1
8 25851691 Effect of lopinavir/ritonavir on the pharmacokinetics of selexipag an oral prostacyclin receptor agonist and its active metabolite in healthy subjects. Br J Clin Pharmacol 2015 Oct 1
9 26152132 Bioequivalence of different dose-strength tablets of selexipag, a selective prostacyclin receptor agonist, in a multiple-dose up-titration study. Int J Clin Pharmacol Ther 2015 Sep 2
10 26291199 Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. J Med Chem 2015 Sep 24 1
11 26846322 Selexipag: First Global Approval. Drugs 2016 Mar 1
12 27062188 Pharmacokinetics of the novel oral prostacyclin receptor agonist selexipag in subjects with hepatic or renal impairment. Br J Clin Pharmacol 2016 Aug 2
13 27063071 Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects. Clin Ther 2016 May 1
14 27491673 A Contemporary Approach to Pulmonary Arterial Hypertension. Curr Atheroscler Rep 2016 Sep 1
15 27895464 Selexipag in the treatment of pulmonary arterial hypertension: design, development, and therapy. Drug Des Devel Ther 2016 1
16 27919660 A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries. Eur J Pharmacol 2017 Jan 15 2
17 28277164 Pharmacokinetics of the selective prostacyclin receptor agonist selexipag in rats, dogs and monkeys. Xenobiotica 2018 Feb 2
18 28399721 The prostacyclin pathway in pulmonary arterial hypertension: a clinical review. Expert Rev Respir Med 2017 Jun 1
19 28420826 Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension. Circ J 2017 Aug 25 3
20 28478717 Selexipag, an Oral Prostacyclin-Receptor Agonist for Pulmonary Arterial Hypertension. Ann Pharmacother 2017 Jun 1
21 28494686 Clinical pharmacology, efficacy, and safety of selexipag for the treatment of pulmonary arterial hypertension. Expert Opin Drug Saf 2017 Jun 1
22 28524738 Selexipag, a selective prostacyclin receptor agonist in pulmonary arterial hypertension: a pharmacology review. Expert Rev Clin Pharmacol 2017 Jul 2
23 28639119 A pharmacokinetic drug-drug interaction study between selexipag and midazolam, a CYP3A4 substrate, in healthy male subjects. Eur J Clin Pharmacol 2017 Sep 5
24 28639216 Biocomparison Study of Adult and Paediatric Dose Strengths of the Prostacyclin Receptor Agonist Selexipag. Eur J Drug Metab Pharmacokinet 2018 Feb 2
25 28715853 Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects. Br J Clin Pharmacol 2017 Dec 3
26 28737453 The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag. Xenobiotica 2018 Jul 10
27 28818881 Selexipag for the treatment of connective tissue disease-associated pulmonary arterial hypertension. Eur Respir J 2017 Aug 9
28 29073911 Successful transition from Treprostinil to Selexipag in patient with severe pulmonary arterial hypertension. BMC Pulm Med 2017 Oct 26 1
29 29468921 Cross-species comparison of the metabolism and excretion of selexipag. Xenobiotica 2019 Mar 1
30 29588339 Selective Prostacyclin Receptor Agonist Selexipag, in Contrast to Prostacyclin Analogs, Does Not Evoke Paradoxical Vasoconstriction of the Rat Femoral Artery. J Pharmacol Exp Ther 2018 Jun 3
31 29720235 Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts. Arthritis Res Ther 2018 May 2 2
32 30267780 Contribution of Human Liver and Intestinal Carboxylesterases to the Hydrolysis of Selexipag In Vitro. J Pharm Sci 2019 Feb 9
33 30526673 Determining the value contribution of selexipag for the treatment of pulmonary arterial hypertension (PAH) in Spain using reflective multi-criteria decision analysis (MCDA). Orphanet J Rare Dis 2018 Dec 10 1
34 30671881 Improving Survival in Patients with Pulmonary Arterial Hypertension: Focus on Intravenous Epoprostenol. Am J Cardiovasc Drugs 2019 Apr 1
35 31042010 Prostacyclin for pulmonary arterial hypertension. Cochrane Database Syst Rev 2019 May 1 1
36 32110381 Hemodynamic and clinical effects of selexipag in children with pulmonary hypertension. Pulm Circ 2020 Jan-Mar 1
37 32415684 Clopidogrel, a CYP2C8 inhibitor, causes a clinically relevant increase in the systemic exposure to the active metabolite of selexipag in healthy subjects. Br J Clin Pharmacol 2021 Jan 3
38 32867545 An evaluation of selexipag for the treatment of pulmonary hypertension. Expert Opin Pharmacother 2021 Jan 1
39 32879152 Selexipag for Chronic Thromboembolic Pulmonary Hypertension in Japanese Patients - A Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase II Study. Circ J 2020 Sep 25 1
40 32997809 Clinical evaluation of drug-drug interactions between the cytochrome P450 substrates selexipag and clopidogrel in Japanese volunteers. Br J Clin Pharmacol 2021 Apr 2
41 33057388 The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats. PLoS One 2020 3
42 33526303 Patient and disease characteristics of the first 500 patients with pulmonary arterial hypertension treated with selexipag in real-world settings from SPHERE. J Heart Lung Transplant 2021 Apr 1
43 33539988 Use of the Prostacyclin Receptor Agonist Selexipag in Patients With Pulmonary Arterial Hypertension Associated With Eisenmenger Syndrome. Can J Cardiol 2021 Aug 2
44 33952848 [Pharmacological characteristics and clinical study results of Selexipag (Uptravi<sup>®</sup> tablets), a selective prostacyclin receptor agonist]. Nihon Yakurigaku Zasshi 2021 2
45 34727317 Long-Term Survival, Safety and Tolerability with Selexipag in Patients with Pulmonary Arterial Hypertension: Results from GRIPHON and its Open-Label Extension. Adv Ther 2022 Jan 1
46 35598975 Selexipag improves Lipopolysaccharide-induced ARDS on C57BL/6 mice by modulating the cAMP/PKA and cAMP/Epac1 signaling pathways. Biol Pharm Bull 2022 May 20 1