| 1 | 19402821 | Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). | Biochem J | 2009 Jun 12 |
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| 2 | 20884880 | The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts. | Circ Res | 2010 Nov 12 |
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| 3 | 21956113 | Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. | J Biol Chem | 2011 Nov 11 |
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| 4 | 22223645 | Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. | J Biol Chem | 2012 Mar 23 |
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| 5 | 22415236 | The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition. | Br J Cancer | 2012 Apr 10 |
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| 6 | 22452883 | Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin. | Mol Cancer Res | 2012 Jun |
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| 7 | 22619175 | Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1. | J Biol Chem | 2012 Jul 6 |
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| 8 | 22885370 | Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels. | Oncotarget | 2012 Aug |
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| 9 | 23303455 | Potent dual inhibitors of TORC1 and TORC2 complexes (KU-0063794 and KU-0068650) demonstrate in vitro and ex vivo anti-keloid scar activity. | J Invest Dermatol | 2013 May |
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| 10 | 23349989 | A comparison of Ku0063794, a dual mTORC1 and mTORC2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models. | PLoS One | 2013 |
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| 11 | 23437362 | Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells. | PLoS One | 2013 |
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| 12 | 23661091 | mTOR pathway and Ca²⁺ stores mobilization in aged smooth muscle cells. | Aging (Albany NY) | 2013 May |
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| 13 | 23840605 | Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines. | PLoS One | 2013 |
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| 14 | 23874880 | Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells. | PLoS One | 2013 |
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| 15 | 23940704 | Requirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibition. | PLoS One | 2013 |
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| 16 | 23958999 | Nitric oxide regulates AKT phosphorylation and nuclear translocation in cultured retinal cells. | Cell Signal | 2013 Dec |
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| 17 | 24036423 | Short term exposure to elevated levels of leptin reduces proximal tubule cell metabolic activity. | Mol Cell Endocrinol | 2014 Jan 25 |
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| 18 | 24800098 | Differential Role of Rapamycin and Torin/KU63794 in Inflammatory Response of 264.7 RAW Macrophages Stimulated by CA-MRSA. | Int J Inflam | 2014 |
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| 19 | 25393730 | Mammalian target of rapamycin complex 2 signaling pathway regulates transient receptor potential cation channel 6 in podocytes. | PLoS One | 2014 |
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| 20 | 25618298 | Significance of 4E-binding protein 1 as a therapeutic target for invasive urothelial carcinoma of the bladder. | Urol Oncol | 2015 Apr |
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| 21 | 26148118 | Potentiation of Growth Inhibitory Responses of the mTOR Inhibitor Everolimus by Dual mTORC1/2 Inhibitors in Cultured Breast Cancer Cell Lines. | PLoS One | 2015 |
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| 22 | 26278819 | Autophagy inhibition sensitizes KU-0063794-mediated anti-HepG2 hepatocellular carcinoma cell activity in vitro and in vivo. | Biochem Biophys Res Commun | 2015 Sep 25 |
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| 23 | 26960330 | KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice. | Mol Neurobiol | 2017 May |
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| 24 | 27014314 | Target of Rapamycin Is a Key Player for Auxin Signaling Transduction in Arabidopsis. | Front Plant Sci | 2016 |
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| 25 | 27935857 | Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells. | Oncotarget | 2017 Jan 10 |
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| 26 | 27960162 | The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis. | Cell Physiol Biochem | 2016 |
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| 27 | 28396518 | Rapamycin efficiently promotes cardiac differentiation of mouse embryonic stem cells. | Biosci Rep | 2017 Jun 30 |
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| 28 | 28410220 | Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling. | Oncotarget | 2017 May 23 |
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| 29 | 28427860 | Differential mTOR pathway profiles in bladder cancer cell line subtypes to predict sensitivity to mTOR inhibition. | Urol Oncol | 2017 Oct |
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| 30 | 28553309 | The TOR Pathway Is Involved in Adventitious Root Formation in <i>Arabidopsis</i> and Potato. | Front Plant Sci | 2017 |
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| 31 | 28915623 | Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer. | Oncotarget | 2017 Aug 22 |
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| 32 | 29121714 | Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy. | Cancer Res Treat | 2018 Jul |
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| 33 | 30906437 | Role of mTOR signaling in the regulation of high glucose-induced podocyte injury. | Exp Ther Med | 2019 Apr |
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| 34 | 31499159 | mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation. | Biochim Biophys Acta Mol Basis Dis | 2019 Dec 1 |
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| 35 | 31726709 | A Newly Established Murine Cell Line as a Model for Hepatocellular Cancer in Non-Alcoholic Steatohepatitis. | Int J Mol Sci | 2019 Nov 12 |
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| 36 | 32736679 | The role of PI3K/Akt/mTOR signaling in dose-dependent biphasic effects of glycine on vascular development. | Biochem Biophys Res Commun | 2020 Aug 27 |
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| 37 | 32851605 | Prevention of Akt phosphorylation is a key to targeting cancer stem-like cells by mTOR inhibition. | Hum Cell | 2020 Oct |
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| 38 | 32879215 | β-Estradiol Enhanced Secretion of Lipoprotein Lipase from Mouse Mammary Tumor FM3A Cells. | Biol Pharm Bull | 2020 |
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| 39 | 33799789 | Combining Everolimus and Ku0063794 Promotes Apoptosis of Hepatocellular Carcinoma Cells via Reduced Autophagy Resulting from Diminished Expression of miR-4790-3p. | Int J Mol Sci | 2021 Mar 11 |
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| 40 | 33831291 | Potentiation of the Anticancer Effects by Combining Docetaxel with Ku-0063794 against Triple-Negative Breast Cancer Cells. | Cancer Res Treat | 2022 Jan |
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| 41 | 34245104 | The inhibition of mammalian target of rapamycin (mTOR) in improving inflammatory response after traumatic brain injury. | J Cell Mol Med | 2021 Aug |
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| 42 | 35400284 | Matrine Combined with Mammalian Target of Rapamycin Inhibitor Enhances Anti-Tumor Efficacy of dendritic cell Vaccines in hepatocellular carcinoma. | Bioengineered | 2022 Apr |
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