| 1 | 16765943 | (R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastoma cells to nutlin-3-induced apoptosis. | Exp Cell Res | 2006 Jul 15 |
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| 2 | 16778203 | The epithelial cell transforming sequence 2, a guanine nucleotide exchange factor for Rho GTPases, is repressed by p53 via protein methyltransferases and is required for G1-S transition. | Cancer Res | 2006 Jun 15 |
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| 3 | 16949053 | Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors. | Biochem Pharmacol | 2006 Oct 16 |
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| 4 | 17079445 | Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy. | Cancer Res | 2006 Nov 1 |
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| 5 | 17138942 | Antiangiogenic activity of the MDM2 antagonist nutlin-3. | Circ Res | 2007 Jan 5 |
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| 6 | 17146434 | Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. | Oncogene | 2007 May 24 |
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| 7 | 17354236 | Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A. | Int J Cancer | 2007 Jul 1 |
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| 8 | 17364023 | Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas. | J Clin Invest | 2007 Apr |
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| 9 | 17440969 | Analysis of the MDM2 antagonist nutlin-3 in human prostate cancer cells. | Prostate | 2007 Jun 1 |
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| 10 | 17504227 | Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells. | Curr Drug Metab | 2007 May |
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| 11 | 17700533 | HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. | Oncogene | 2008 Feb 7 |
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| 12 | 17709487 | Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells. | J Immunol | 2007 Sep 1 |
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| 13 | 17897804 | Exploration of liquid and supercritical fluid chromatographic chiral separation and purification of Nutlin-3--a small molecule antagonist of MDM2. | J Pharm Biomed Anal | 2007 Dec 21 |
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| 14 | 17942917 | p53-mediated growth suppression in response to Nutlin-3 in cyclin D1 transformed cells occurs independently of p21. | Cancer Res | 2007 Oct 15 |
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| 15 | 17957141 | Stimulus-specific transcriptional regulation within the p53 network. | Cell Cycle | 2007 Nov 1 |
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| 16 | 17998303 | Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells. | J Leukoc Biol | 2008 Feb |
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| 17 | 18092340 | Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells. | J Cell Biochem | 2008 May 15 |
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| 18 | 18273046 | MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2. | Leukemia | 2008 Apr |
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| 19 | 18483299 | Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells. | Mol Cancer Ther | 2008 May |
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| 20 | 18521084 | E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. | Oncogene | 2008 Sep 11 |
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| 21 | 18567799 | Mdm2 and Mdm4 loss regulates distinct p53 activities. | Mol Cancer Res | 2008 Jun |
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| 22 | 18625847 | BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways. | J Cell Biol | 2008 Jul 14 |
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| 23 | 18646312 | Disruption of the p53-Mdm2 complex by Nutlin-3 reveals different cancer cell phenotypes. | Ethn Dis | 2008 Spring |
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| 24 | 18677110 | Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. | Cell Cycle | 2008 Aug |
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| 25 | 18725577 | SNP309 as predictor for sensitivity of CLL cells to the MDM2 inhibitor nutlin-3a. | Blood | 2008 Sep 1 |
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| 26 | 18779328 | Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. | J Biol Chem | 2008 Nov 7 |
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| 27 | 18971636 | RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53. | Cell Cycle | 2008 Nov 1 |
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| 28 | 19188164 | MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle cell lymphoma. | Clin Cancer Res | 2009 Feb 1 |
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| 29 | 19190243 | Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism. | Blood | 2009 Apr 30 |
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| 30 | 19385969 | Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. | Cancer Sci | 2009 Jun |
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| 31 | 19421231 | Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells. | Leukemia | 2009 Sep |
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| 32 | 19509161 | Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells. | Clin Cancer Res | 2009 Jun 15 |
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| 33 | 19519319 | Exposure of B cell chronic lymphocytic leukemia (B-CLL) cells to nutlin-3 induces a characteristic gene expression profile, which correlates with nutlin-3-mediated cytotoxicity. | Curr Cancer Drug Targets | 2009 Jun |
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| 34 | 19560254 | Therapeutic potential of Mdm2 inhibition in malignant germ cell tumours. | Eur Urol | 2010 Apr |
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| 35 | 19638586 | HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA. | Cancer Res | 2009 Aug 1 |
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| 36 | 19788889 | DNA damage response to the Mdm2 inhibitor nutlin-3. | Biochem Pharmacol | 2010 Feb 15 |
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| 37 | 19855165 | Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A. | Cell Cycle | 2009 Nov 15 |
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| 38 | 19885598 | High level MycN expression in non-MYCN amplified neuroblastoma is induced by the combination treatment nutlin-3 and doxorubicin and enhances chemosensitivity. | Oncol Rep | 2009 Dec |
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| 39 | 19903807 | Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53. | J Natl Cancer Inst | 2009 Nov 18 |
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| 40 | 19946262 | Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis. | Leukemia | 2010 Jan |
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| 41 | 20080757 | The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. | Proc Natl Acad Sci U S A | 2010 Jan 12 |
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| 42 | 20094798 | Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway. | Apoptosis | 2010 May |
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| 43 | 20157557 | Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3. | Aging (Albany NY) | 2009 Sep 25 |
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| 44 | 20178585 | Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment. | BMC Cancer | 2010 Feb 23 |
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| 45 | 20215498 | Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. | Cancer Res | 2010 Mar 15 |
3 |
| 46 | 20215548 | The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells. | Clin Cancer Res | 2010 Mar 15 |
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| 47 | 20305378 | Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis. | Cell Cycle | 2010 Apr 1 |
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| 48 | 20422343 | Disruption of p73-MDM2 binding synergizes with gemcitabine to induce apoptosis in HuCCT1 cholangiocarcinoma cell line with p53 mutation. | Tumour Biol | 2010 Aug |
3 |
| 49 | 20588277 | Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53. | Br J Cancer | 2010 Jul 13 |
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| 50 | 20812030 | Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. | Apoptosis | 2011 Jan |
3 |