schizandrin A






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1 17129588 Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1. Life Sci 2007 Jan 30 5
2 17566147 Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2. Planta Med 2007 May 2
3 17950515 Molecular mechanism of apoptosis induced by schizandrae-derived lignans in human leukemia HL-60 cells. Food Chem Toxicol 2008 Feb 5
4 20448858 Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity. Methods Find Exp Clin Pharmacol 2010 Apr 6
5 20628932 Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A. J Asian Nat Prod Res 2010 Jul 1
6 20664957 Deoxyschisandrin inhibits H2O2-induced apoptotic cell death in intestinal epithelial cells through nuclear factor-kappaB. Int J Mol Med 2010 Sep 6
7 21351579 [Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A]. Yao Xue Xue Bao 2010 Sep 2
8 21895978 Inhibitory effects of continuous ingestion of Schisandrin A on CYP3A in the rat. Basic Clin Pharmacol Toxicol 2012 Feb 3
9 23339253 Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herb–drug interaction. Fitoterapia 2012 Dec 3
10 23691032 Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One 2013 1
11 24131672 Deoxyschizandrin, a naturally occurring lignan, is a specific probe substrate of human cytochrome P450 3A. Drug Metab Dispos 2014 Jan 7
12 24475039 Schisandra chinensis peptidoglycan-assisted transmembrane transport of lignans uniquely altered the pharmacokinetic and pharmacodynamic mechanisms in human HepG2 cell model. PLoS One 2014 1
13 24786236 Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro. Acta Pharmacol Sin 2014 May 1
14 24855828 Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model. Pharmazie 2014 May 1
15 24986222 Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons. J Physiol Biochem 2014 Sep 2
16 24992201 The protective mechanism of schisandrin A in d-galactosamine-induced acute liver injury through activation of autophagy. Pharm Biol 2014 Oct 7
17 25975095 Schisandrin A and B induce organic anion transporting polypeptide 1B1 transporter activity. Pharmazie 2015 Jan 4
18 26919063 Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways. PLoS One 2016 9
19 27195753 Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response. PLoS One 2016 1
20 28604846 Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach. Mol Biosyst 2017 Jul 25 4
21 28945011 Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling. Basic Clin Pharmacol Toxicol 2018 Mar 2
22 29115385 Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling. Int J Mol Med 2018 Jan 10
23 29181822 Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation. Breast Cancer 2018 Mar 6
24 29331856 RETRACTED: Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195. Biomed Pharmacother 2018 Mar 1
25 29342940 Deoxyschizandrin, Isolated from Schisandra Berries, Induces Cell Cycle Arrest in Ovarian Cancer Cells and Inhibits the Protumoural Activation of Tumour-Associated Macrophages. Nutrients 2018 Jan 15 7
26 29359345 Simultaneous identification of the anaphylactoid components from traditional Chinese medicine injections using rat basophilic leukemia 2H3 and laboratory of allergic disease 2 dual-mixed/cell membrane chromatography model. Electrophoresis 2018 May 1
27 29405807 Interaction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3. Xenobiotica 2019 Feb 8
28 29911779 [Inhibitory effect and mechanism of deoxyschizandrin on NLRP3 inflammasome]. Yao Xue Xue Bao 2017 Jan 10
29 30119261 Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells. Biomed Pharmacother 2018 Oct 2
30 30486721 Evaluation of the inhibition of human carboxylesterases (CESs) by the active ingredients from <i>Schisandra chinensis</i>. Xenobiotica 2019 Nov 1
31 30761007 Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes. Front Pharmacol 2019 10
32 30787979 Schizandrin A protects against cerebral ischemia-reperfusion injury by suppressing inflammation and oxidative stress and regulating the AMPK/Nrf2 pathway regulation. Am J Transl Res 2019 3
33 30909188 Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429. Cancer Biomark 2019 1
34 31028739 Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF-κB signaling in non-small cell lung cancer. Eur J Pharmacol 2019 Jul 15 13
35 31552591 Schisandrin A ameliorates MPTP-induced Parkinson's disease in a mouse model via regulation of brain autophagy. Arch Pharm Res 2019 Nov 6
36 31597329 Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway. Molecules 2019 Oct 8 12
37 31618367 Schizandrin A exerts anti-tumor effects on A375 cells by down-regulating H19. Braz J Med Biol Res 2019 11
38 31767544 Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy. Int Immunopharmacol 2020 Jan 11
39 31794890 Schizandrin A Protects Human Retinal Pigment Epithelial Cell Line ARPE-19 against HG-Induced Cell Injury by Regulation of miR-145. Mol Ther Nucleic Acids 2020 Mar 6 16
40 31844123 Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation. Sci Rep 2019 Dec 16 2
41 31871476 Effects of Deoxyschisandrin on Visceral Sensitivity of Mice with Inflammatory Bowel Disease. Evid Based Complement Alternat Med 2019 5
42 32057180 MEG3 is restored by schisandrin A and represses tumor growth in choriocarcinoma cells. J Biochem Mol Toxicol 2020 Apr 11
43 32058027 Schizandrin attenuates lung lesions induced by Avian pathogenic Escherichia coli in chickens. Microb Pathog 2020 Feb 11 5
44 32076762 Evidence of anti-inflammatory activity of Schizandrin A in animal models of acute inflammation. Naunyn Schmiedebergs Arch Pharmacol 2020 Nov 1
45 32110802 Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1. Biosci Rep 2020 Mar 27 5
46 32274105 Schisandra A ameliorates cigarette smoke extract and lipopolysaccharide-induced oxidative stress in lung epithelial cells. J Thorac Dis 2020 Mar 2
47 32354126 Preventive Effects of Schisandrin A, A Bioactive Component of <i>Schisandra chinensis</i>, on Dexamethasone-Induced Muscle Atrophy. Nutrients 2020 Apr 28 8
48 32623835 Schizandrin A inhibits cellular phenotypes of breast cancer cells by repressing miR-155. IUBMB Life 2020 Aug 6
49 32871020 Schisandrin A restrains osteoclastogenesis by inhibiting reactive oxygen species and activating Nrf2 signalling. Cell Prolif 2020 Oct 15
50 33232930 Interactions of the major effective components in Shengmai formula with breast cancer resistance protein at the cellular and vesicular levels. Biomed Pharmacother 2021 Jan 1