2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine






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1 7477899 Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect? Neuroscience 1995 Jul 1
2 7599925 Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors. Br J Pharmacol 1995 Apr 2
3 7858863 Failure of CGS15943A to block the hypotensive action of agonists acting at the adenosine A3 receptor. Br J Pharmacol 1994 Nov 1
4 8026549 Activation of adenosine A1 receptors underlies anticonvulsant effect of CGS21680. Eur J Pharmacol 1994 Apr 1 1
5 8913778 Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors. Glia 1996 Oct 3
6 9030695 Stimulation of the A2A adenosine receptor increases expression of the tyrosine hydroxylase gene. Brain Res Mol Brain Res 1997 Feb 4
7 9458912 Fetal cardiovascular and breathing responses to an adenosine A2a receptor agonist in sheep. Am J Physiol 1998 Jan 1
8 9515570 Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells. Biochem Pharmacol 1998 Mar 1 1
9 9541735 Adenosine receptor-mediated inhibition of neurite outgrowth from cultured sensory neurons is via an A1 receptor and is reduced by nerve growth factor. Brain Res Dev Brain Res 1998 Feb 10 2
10 9763626 Chronic hypoxia reduces adenosine A2A receptor-mediated inhibition of calcium current in rat PC12 cells via downregulation of protein kinase A. J Physiol 1998 Oct 15 1
11 10215911 Region-dependent difference in the sleep-promoting potency of an adenosine A2A receptor agonist. Eur J Neurosci 1999 May 1
12 10627457 Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases. Blood 2000 Jan 15 2
13 10694235 Effects of P(1) and P2 receptor antagonists on beta, gamma-methyleneATP- and CGS21680-induced cyclic AMP formation in NG108-15 cells. Br J Pharmacol 2000 Jan 2
14 10733693 Strong rebound of wakefulness follows prostaglandin D2- or adenosine A2a receptor agonist-induced sleep. J Sleep Res 2000 Mar 1
15 10869376 Down-regulation of vascular endothelial growth factor expression after A(2A) adenosine receptor activation in PC12 pheochromocytoma cells. J Pharmacol Exp Ther 2000 Jun 1
16 10945856 Adenosine and selective A(2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation. J Pharmacol Exp Ther 2000 Sep 1
17 11124829 Signal pathway involved in the development of hypoxic preconditioning in rat hepatocytes. Hepatology 2001 Jan 1
18 11172060 The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proc Natl Acad Sci U S A 2001 Feb 13 1
19 11240123 Stimulation of p38 MAP kinase reduces acidosis and Na(+) overload in preconditioned hepatocytes. FEBS Lett 2001 Mar 2 1
20 11564822 Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells. J Immunol 2001 Oct 1 3
21 11717194 Adenosine regulates the IL-1 beta-induced cellular functions of human gingival fibroblasts. Int Immunol 2001 Dec 2
22 11720788 An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience 2001 2
23 11818459 Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: impact on phospholipase D activity and recruitment of small GTPases to membranes. J Leukoc Biol 2002 Feb 1
24 11909610 Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat. Eur J Pharmacol 2002 Mar 8 1
25 12097306 Activation of adenosine-receptor-enhanced iNOS mRNA expression by gingival epithelial cells. J Dent Res 2002 Apr 1
26 12114502 Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade. J Biol Chem 2002 Sep 13 4
27 12231386 Adenosine A2A receptors inhibit the N-methyl-D-aspartate component of excitatory synaptic currents in rat striatal neurons. Eur J Pharmacol 2002 Sep 13 1
28 12590138 Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells. J Biol Chem 2003 Apr 25 1
29 14751293 Stimulation of adenosine A2A receptors elicits zif/268 and NMDA epsilon2 subunit mRNA expression in cortex and striatum of the "weaver" mutant mouse, a genetic model of nigrostriatal dopamine deficiency. Neuroscience 2004 4
30 15211592 Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal. J Neurosci Res 2004 Jul 15 2
31 15239970 Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal piglets. Respir Physiol Neurobiol 2004 Jul 20 1
32 15265768 Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb. Am J Physiol Renal Physiol 2004 Nov 2
33 15342103 Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease. Brain Res Bull 2004 Aug 30 1
34 15602796 Subtypes of adenosine receptors on pancreatic exocrine secretion in anaesthetized dogs. Fundam Clin Pharmacol 2000 May-Jun 1
35 15634932 A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells. J Immunol 2005 Jan 15 2
36 15665505 Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells. Cell Struct Funct 2004 Dec 3
37 15816854 CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model. J Neurochem 2005 Apr 3
38 16177079 Gs protein-coupled adenosine receptor signaling and lytic function of activated NK cells. J Immunol 2005 Oct 1 1
39 16501051 Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. J Leukoc Biol 2006 May 1
40 16621044 Expression pattern of FOS in orexin neurons during sleep induced by an adenosine A2A receptor agonist. Behav Brain Res 2006 Jun 30 1
41 16644907 Activation of adenosine A2A receptors alters postsynaptic currents and depolarizes neurons of the supraoptic nucleus. Am J Physiol Regul Integr Comp Physiol 2006 Aug 1
42 16917093 Adenosine inhibits matrix metalloproteinase-9 secretion by neutrophils: implication of A2a receptor and cAMP/PKA/Ca2+ pathway. Circ Res 2006 Sep 15 1
43 16963274 The effect of adenosine receptor agonists on cytokine release by human mononuclear cells depends on the specific Toll-like receptor subtype used for stimulation. Cytokine 2006 Jul 5
44 17321471 The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol 2007 Apr 1
45 17474152 Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. Eur J Immunol 2007 Jun 1
46 17575165 Inhibition of cytokine production and cytotoxic activity of human antimelanoma specific CD8+ and CD4+ T lymphocytes by adenosine-protein kinase A type I signaling. Cancer Res 2007 Jun 15 3
47 17974599 Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors. Am J Pathol 2007 Dec 2
48 18054436 A1 and A2A receptor activation by endogenous adenosine is required for VIP enhancement of K+ -evoked [3H]-GABA release from rat hippocampal nerve terminals. Neurosci Lett 2008 Jan 17 2
49 18384819 Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine. Neuropharmacology 2008 May 1
50 18519569 Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. J Biol Chem 2008 Jul 25 6