Pemetrexed






640 Article(s)
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1 7537518 Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines. Br J Cancer 1995 May 1
2 7565626 Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity. Mol Pharmacol 1995 Sep 1
3 7595747 Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation. J Clin Oncol 1995 Nov 2
4 8044293 Column-switching high-performance liquid chromatographic method for the determination of a thymidylate synthase inhibitor, LY231514, an investigational agent for the treatment of solid tumors, in human plasma. J Chromatogr B Biomed Appl 1994 Apr 1 1
5 9067281 LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997 Mar 15 10
6 9533527 A phase I and pharmacokinetic study of LY231514, the multitargeted antifolate. Clin Cancer Res 1998 Mar 1
7 9717988 Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Br J Cancer 1998 4
8 9762351 Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). Adv Enzyme Regul 1998 4
9 9858888 Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514. Anticancer Res 1998 Sep-Oct 1
10 10226579 Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514. Anticancer Res 1999 Jan-Feb 2
11 10545786 Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer. Oncology 1999 Oct 1
12 10598557 Prevention of thymidine and hypoxanthine rescue from MTA (LY231514) growth inhibition by dipyridamole in human lung cancer cell lines. Semin Oncol 1999 Apr 2
13 10598560 Overview of phase I trials of multitargeted antifolate (MTA, LY231514). Semin Oncol 1999 Apr 2
14 10598563 Overview of phase II trials of MTA in solid tumors. Semin Oncol 1999 Apr 2
15 10732767 Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport. Br J Cancer 2000 Feb 1
16 10847455 Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors. Ann Oncol 2000 Apr 3
17 11252887 Gemcitabine and Pemetrexed disodium in treating breast cancer. Oncology (Williston Park) 2001 Feb 4
18 11384244 Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. J Med Chem 2001 Jun 7 3
19 11417748 Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates. Oncol Res 2000 4
20 11524555 Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist 2001 1
21 11531245 Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck. Br J Cancer 2001 Sep 1 2
22 11742712 Gemcitabine and pemetrexed disodium combinations in vitro and in vivo. Lung Cancer 2001 Dec 4
23 11763166 Pemetrexed disodium (Eli Lilly). Curr Opin Investig Drugs 2001 Nov 7
24 11848474 Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells. Anticancer Res 2001 Sep-Oct 1
25 12023790 Pemetrexed for diffuse malignant pleural mesothelioma. Semin Oncol 2002 Apr 1
26 12023791 Pemetrexed: a promising new treatment for breast cancer. Semin Oncol 2002 Apr 2
27 12023793 Pemetrexed in the treatment of selected solid tumors. Semin Oncol 2002 Apr 2
28 12023794 Future directions in the development of pemetrexed. Semin Oncol 2002 Apr 1
29 12094334 Incorporation of pemetrexed (Alimta) into the treatment of non-small cell lung cancer (thoracic tumors). Semin Oncol 2002 Jun 2
30 12094337 Pemetrexed: translational research in breast cancer. Semin Oncol 2002 Jun 2
31 12118332 Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells. Int J Oncol 2002 Aug 2
32 12209673 The pemetrexed/gemcitabine combination in pancreatic cancer. Cancer 2002 Aug 15 2
33 12437479 Pharmacogenomic strategies for developing customized chemotherapy in non-small cell lung cancer. Pharmacogenomics 2002 Nov 1
34 12450432 Thymidylate synthase pharmacogenetics in colorectal cancer. Clin Colorectal Cancer 2001 Nov 2
35 12571807 Pemetrexed safety and dosing strategy. Semin Oncol 2002 Dec 2
36 12571808 Preclinical and clinical studies with combinations of pemetrexed and gemcitabine. Semin Oncol 2002 Dec 2
37 12571811 Pemetrexed in pancreatic cancer. Semin Oncol 2002 Dec 2
38 12571812 The role of pemetrexed in the treatment of colorectal cancer. Semin Oncol 2002 Dec 1
39 12571813 Pemetrexed: an active new agent for breast cancer. Semin Oncol 2002 Dec 2
40 12663051 Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. Biochem Pharmacol 2003 Apr 1 2
41 12720495 Pemetrexed and its emerging role in the treatment of thoracic malignancies. Expert Opin Investig Drugs 2003 May 1
42 12722017 Pemetrexed (Alimta): a promising new agent for the treatment of breast cancer. Semin Oncol 2003 Apr 2
43 12860938 Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003 Jul 15 1
44 12907242 Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression. Biochem Pharmacol 2003 Aug 1 6
45 14596699 The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy. Clin Lung Cancer 2003 Jul 2
46 14871988 The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clin Cancer Res 2004 Feb 1 1
47 14981587 Pemetrexed for treatment of advanced non-small cell lung cancer. Semin Oncol 2004 Feb 1
48 15117425 Pharmacology and mechanism of action of pemetrexed. Clin Lung Cancer 2004 Apr 1
49 15117426 Pemetrexed alone and in combination with platinum compounds in the management of malignant mesothelioma. Clin Lung Cancer 2004 Apr 1
50 15117429 Second-line chemotherapy for non-small-cell lung cancer: recent data with pemetrexed. Clin Lung Cancer 2004 Apr 1