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1 |
2 | 10077432 | Identification of metabolites of NK-104, an HMG-CoA reductase inhibitor, in rat, rabbit and dog bile. | Biol Pharm Bull | 1999 Feb |
1 |
3 | 10202970 | Simultaneous determination of NK-104 and its lactone in biological samples by column-switching high-performance liquid chromatography with ultraviolet detection. | J Chromatogr B Biomed Sci Appl | 1999 Mar 5 |
1 |
4 | 10428299 | NK-104, a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, decreases apolipoprotein B-100 secretion from Hep G2 cells. | Atherosclerosis | 1999 Jul |
4 |
5 | 11325797 | NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells. | Br J Pharmacol | 2001 May |
4 |
6 | 11480454 | Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. | J Atheroscler Thromb | 2000 |
4 |
7 | 11554731 | Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. | Biochem Biophys Res Commun | 2001 Sep 21 |
4 |
8 | 11779144 | Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB. | Biochem Biophys Res Commun | 2002 Jan 11 |
3 |
9 | 11900720 | Managing dyslipidemia in the high-risk patient. | Am J Cardiol | 2002 Mar 7 |
1 |
10 | 11996957 | A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia. | Atherosclerosis | 2002 Jun |
1 |
11 | 12040967 | Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison. | Arzneimittelforschung | 2002 |
1 |
12 | 12047044 | Inhibition of migration and proliferation of rat vascular smooth muscle cells by a new HMG-CoA reductase inhibitor, pitavastatin. | Hypertens Res | 2002 Mar |
5 |
13 | 12191589 | Triglyceride-lowering effect of pitavastatin [corrected] in a rat model of postprandial lipemia. | Eur J Pharmacol | 2002 May 24 |
3 |
14 | 12231401 | HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes. | Life Sci | 2002 Oct 4 |
1 |
15 | 12442637 | Metabolic fate of pitavastatin (NK-104), a new inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase. Effects on drug-metabolizing systems in rats and humans. | Arzneimittelforschung | 2002 |
1 |
16 | 12486415 | Management of dyslipidemia in the high-risk patient. | Am Heart J | 2002 Dec |
1 |
17 | 12498010 | Pitavastatin Nissan/Kowa Yakuhin/Novartis/Sankyo. | Curr Opin Investig Drugs | 2002 Sep |
2 |
18 | 12519692 | Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. | Xenobiotica | 2003 Jan |
6 |
19 | 12621163 | Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2. | J Atheroscler Thromb | 2003 |
8 |
20 | 12705169 | Triglyceride-lowering effect of pitavastatin in a guinea pig model of postprandial lipemia. | Arzneimittelforschung | 2003 |
7 |
21 | 12740485 | Plaque-stabilizing effect of pitavastatin in Watanabe heritable hyperlipidemic (WHHL) rabbits. | J Atheroscler Thromb | 2003 |
4 |
22 | 12743630 | Pitavastatin (NK-104), a new HMG-CoA reductase inhibitor. | Drugs Today (Barc) | 2001 Sep |
2 |
23 | 12880107 | Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice. | Lipids | 2003 May |
1 |
24 | 12938153 | Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells. | J Cell Biochem | 2003 Sep 1 |
12 |
25 | 14733921 | Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. | Biochem Biophys Res Commun | 2004 Feb 6 |
2 |
26 | 14969717 | Anti-lipid deposition effect of HMG-CoA reductase inhibitor, pitavastatin, in a rat model of hypertension and hypercholesterolemia. | Life Sci | 2004 Mar 12 |
1 |
27 | 15049129 | The novel HMG-CoA reductase inhibitor, Pitavastatin, induces a protective action in vascular endothelial cells through the production of nitric oxide (NO). | Yakugaku Zasshi | 2004 Mar |
4 |
28 | 15118259 | [Pharmacological and pharmacokinetic features and clinical effects of pitavastatin (Livalo Tablet)]. | Nihon Yakurigaku Zasshi | 2004 May |
5 |
29 | 15159445 | Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. | J Pharmacol Exp Ther | 2004 Oct |
13 |
30 | 15166180 | Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis. | Hypertension | 2004 Jun |
1 |
31 | 15167274 | Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, blocks vascular smooth muscle cell populated-collagen lattice contraction. | J Cardiovasc Pharmacol | 2004 Jun |
1 |
32 | 15234191 | MCP-1-induced enhancement of THP-1 adhesion to vascular endothelium was modulated by HMG-CoA reductase inhibitor through RhoA GTPase-, but not ERK1/2-dependent pathway. | Life Sci | 2004 Jul 30 |
10 |
33 | 15244070 | Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin II receptor blocker, on CCl4-induced liver fibrosis in rats. | J UOEH | 2004 Jun 1 |
2 |
34 | 15283301 | Effect of gemfibrozil on the metabolism of pitavastatin--determining the best animal model for human CYP and UGT activities. | Drug Metabol Drug Interact | 2004 |
7 |
35 | 15292460 | Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier. | J Pharmacol Exp Ther | 2004 Dec |
3 |
36 | 15327760 | Protective effect of pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-induced neuronal damage. | Neurol Res | 2004 Sep |
7 |
37 | 15329062 | Effect of pitavastatin against expression of S100beta protein in the gerbil hippocampus after transient cerebral ischaemia. | Acta Physiol Scand | 2004 Sep |
4 |
38 | 15338328 | Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils. | J Neural Transm (Vienna) | 2004 Sep |
4 |
39 | 15344842 | Metabolic stability and uptake by human hepatocytes of pitavastatin, a new inhibitor of HMG-CoA reductase. | Arzneimittelforschung | 2004 |
7 |
40 | 15358158 | Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. | Biochem Biophys Res Commun | 2004 Aug 27 |
5 |
41 | 15380447 | A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits. | Atherosclerosis | 2004 Oct |
2 |
42 | 15474503 | Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell. | Biochem Biophys Res Commun | 2004 Nov 12 |
10 |
43 | 15485693 | HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells. | Cardiovasc Res | 2004 Nov 1 |
1 |
44 | 15502389 | Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. | Circ J | 2004 Nov |
9 |
45 | 15502390 | Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor. | Circ J | 2004 Nov |
1 |
46 | 15557368 | Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104). | Circulation | 2004 Nov 30 |
5 |
47 | 15591219 | Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism. | Arterioscler Thromb Vasc Biol | 2005 Feb |
3 |
48 | 15618696 | Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase--effect of cMOAT deficiency on hepatobiliary excretion in rats and of mdr1a/b gene disruption on tissue distribution in mice. | Drug Metab Pharmacokinet | 2002 |
3 |
49 | 15618742 | Uptake mechanism of pitavastatin, a new inhibitor of HMG-CoA reductase, in rat hepatocytes. | Drug Metab Pharmacokinet | 2003 |
1 |
50 | 15690306 | Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. | Metabolism | 2005 Feb |
5 |