remdesivir






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1 32222463 Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci 2020 Jul 15 2
2 32277040 Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science 2020 May 15 1
3 32283108 Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites. Antiviral Res 2020 Jun 2
4 32284326 Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. J Biol Chem 2020 May 15 6
5 32338164 SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an <i>in silico</i> perspective. J Biomol Struct Dyn 2021 Jun 1
6 32358203 Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science 2020 Jun 26 3
7 32375574 Repurposing of chloroquine and some clinically approved antiviral drugs as effective therapeutics to prevent cellular entry and replication of coronavirus. J Biomol Struct Dyn 2021 Jul 1
8 32422376 Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe COVID-19: A case report. Int J Infect Dis 2020 Aug 1
9 32492200 Remdesivir and tocilizumab: Mix or match. J Med Virol 2021 Jan 1
10 32511290 Computational target-based drug repurposing of elbasvir, an antiviral drug predicted to bind multiple SARS-CoV-2 proteins. ChemRxiv 2020 Apr 8 1
11 32517353 Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients. J Clin Med 2020 Jun 7 1
12 32521159 Structural Basis of the Potential Binding Mechanism of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase. J Phys Chem B 2020 Aug 13 7
13 32550880 Recommandations EMA sur l’usage compassionnel du remdesivir. Rev Francoph Lab 2020 Jun 1
14 32563812 A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir. Eur J Med Chem 2020 Sep 1 1
15 32568620 Remdesivir (GS-5734) as a therapeutic option of 2019-nCOV main protease - <i>in silico</i> approach. J Biomol Struct Dyn 2021 Aug 1
16 32573468 Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient. Clin Chem Lab Med 2020 Aug 27 1
17 32594120 Drug-induced Liver Injury in a Patient With Coronavirus Disease 2019: Potential Interaction of Remdesivir With P-Glycoprotein Inhibitors. Clin Infect Dis 2021 Apr 8 3
18 32607511 A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19. bioRxiv 2020 Jun 23 1
19 32643603 Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell 2020 Aug 6 2
20 32686993 Network analysis, sequence and structure dynamics of key proteins of coronavirus and human host, and molecular docking of selected phytochemicals of nine medicinal plants. J Biomol Struct Dyn 2021 Oct 4
21 32702590 Intermolecular interaction among Remdesivir, RNA and RNA-dependent RNA polymerase of SARS-CoV-2 analyzed by fragment molecular orbital calculation. J Mol Graph Model 2020 Nov 1
22 32729392 Antiviral potential of some novel structural analogs of standard drugs repurposed for the treatment of COVID-19. J Biomol Struct Dyn 2021 Oct 2
23 32753375 BET 1: The role of remdesivir in COVID-19 infection. Emerg Med J 2020 Aug 1
24 32754599 nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics. Front Cell Dev Biol 2020 1
25 32793908 Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells. bioRxiv 2020 Sep 2 9
26 32834722 ICER update to pricing models of remdesivir for COVID-19. PharmacoEcon Outcomes News 2020 1
27 32836709 Evaluating the potential of different inhibitors on RNA-dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2: A molecular modeling approach. Med J Armed Forces India 2021 Jul 1
28 32869031 Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics. bioRxiv 2020 Aug 28 3
29 32887884 Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun 2020 Sep 4 1
30 32904625 Exploration of inhibitory action of Azo imidazole derivatives against COVID-19 main protease (M<sup>pro</sup>): A computational study. J Mol Struct 2021 Jan 15 1
31 32943188 RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19. Biochem Biophys Res Commun 2021 Jan 29 3
32 32947136 Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19. Bioorg Chem 2020 Nov 1
33 32967965 Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action. J Biol Chem 2020 Nov 20 3
34 33012543 Coronavirus Disease 2019 Viremia, Serologies, and Clinical Course in a Case Series of Transplant Recipients. Transplant Proc 2020 Nov 1
35 33100032 Exploring RdRp-remdesivir interactions to screen RdRp inhibitors for the management of novel coronavirus 2019-nCoV. SAR QSAR Environ Res 2020 Nov 9
36 33102688 <i>In silico</i> identification of drug candidates against COVID-19. Inform Med Unlocked 2020 1
37 33151166 Identification of potential COVID-19 main protease inhibitors using structure-based pharmacophore approach, molecular docking and repurposing studies. Acta Pharm 2021 Jun 1 1
38 33176643 Computational Evidences of Phytochemical Mediated Disruption of PLpro Driven Replication of SARS-CoV-2: A Therapeutic Approach against COVID-19. Curr Pharm Biotechnol 2021 1
39 33179852 Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection. EMBO Mol Med 2021 Jan 11 2
40 33183178 Identification of natural inhibitors against prime targets of SARS-CoV-2 using molecular docking, molecular dynamics simulation and MM-PBSA approaches. J Biomol Struct Dyn 2022 Apr 3
41 33185784 Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment. Protein J 2020 Dec 2
42 33190493 Revealing the Inhibition Mechanism of RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 by Remdesivir and Nucleotide Analogues: A Molecular Dynamics Simulation Study. J Phys Chem B 2020 Nov 25 3
43 33237691 Lipid and Lipoprotein Levels in Patients with COVID-19 Infections 2000 1
44 33245731 MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection. Oncotarget 2020 Nov 17 13
45 33260103 Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2. Comput Biol Med 2021 Feb 6
46 33261845 Computational drug discovery and repurposing for the treatment of COVID-19: A systematic review. Bioorg Chem 2021 Jan 1
47 33262564 ICER's second update to pricing models of remdesivir for COVID-19. PharmacoEcon Outcomes News 2020 1
48 33264025 Remdesivir Strongly Binds to Both RNA-Dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations. J Phys Chem B 2020 Dec 17 10
49 33281478 The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp. Saudi J Biol Sci 2021 Feb 2
50 33283177 Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase. iScience 2020 Dec 18 1