Withanolides






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1 2588305 A convenient preparation of the side-chain lactone ring of a withanolide precursor. Steroids 1989 Sep 1
2 7721954 Integrity of intermediate filaments is associated with the development of acquired thermotolerance in 9L rat brain tumor cells. J Cell Biochem 1995 Jan 1
3 12027740 Induction of quinone reductase by withanolides. J Nat Prod 2002 May 2
4 15326546 Natural inhibitors of carcinogenesis. Planta Med 2004 Aug 1
5 16108094 Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Biochem Biophys Res Commun 2005 Aug 19 4
6 16375970 Biological and molecular docking studies on coagulin-H: Human IL-2 novel natural inhibitor. Mol Immunol 2006 Apr 2
7 16936134 Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization. Invest Ophthalmol Vis Sci 2006 Sep 2
8 17212786 Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells. FEBS J 2006 Dec 1
9 17328876 Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation. Chem Biol Interact 2007 Apr 5 1
10 17513606 A bioactive withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression. Mol Cancer Ther 2007 May 3
11 17562568 Withania somnifera inhibits NF-kappaB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytother Res 2007 Oct 1
12 17874299 Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine. Apoptosis 2007 Nov 2
13 19049961 Tubocapsanolide A inhibits transforming growth factor-beta-activating kinase 1 to suppress NF-kappaB-induced CCR7. J Biol Chem 2009 Jan 30 1
14 19152372 Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation. Phytother Res 2009 Jul 1
15 19628058 Molecular insight into the immune up-regulatory properties of the leaf extract of Ashwagandha and identification of Th1 immunostimulatory chemical entity. Vaccine 2009 Oct 9 2
16 19687301 Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells. Mol Cell Biol 2009 Oct 2
17 20438092 Antiproliferative activity of withanolides against human breast cancer cell lines. J Nat Prod 2010 May 28 1
18 20438634 Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. Mol Cancer 2010 May 3 1
19 22425978 Molecular cloning, bacterial expression and promoter analysis of squalene synthase from Withania somnifera (L.) Dunal. Gene 2012 May 10 2
20 22477711 Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation. Tumour Biol 2012 Aug 2
21 22479585 Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PLoS One 2012 4
22 22701533 Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90. PLoS One 2012 13
23 22713947 Molecular docking studies of withanolides against Cox-2 enzyme. Pak J Pharm Sci 2012 Jul 2
24 22842101 Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development. N Biotechnol 2013 Jan 25 1
25 23158190 Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway. Surgery 2012 Dec 8
26 23252848 Antiproliferative withanolides from Datura wrightii. J Nat Prod 2013 Mar 22 1
27 23887853 Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells. Invest New Drugs 2014 Feb 7
28 24252344 A withanolide coagulin-L inhibits adipogenesis modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion. Phytomedicine 2014 Mar 15 1
29 24763440 Withanolides are potent novel targeted therapeutic agents against adrenocortical carcinomas. World J Surg 2014 Jun 3
30 24900739 Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation. ACS Med Chem Lett 2013 Aug 8 3
31 25719250 Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell Death Dis 2015 Feb 26 6
32 25969759 Withaferin a induces proteasome-dependent degradation of breast cancer susceptibility gene 1 and heat shock factor 1 proteins in breast cancer cells. ISRN Biochem 2012 3
33 26527154 Withanolides: Biologically Active Constituents in the Treatment of Alzheimer's Disease. Med Chem 2016 1
34 26941790 Methanolic Extract of Ceplukan Leaf (Physalis minima L.) Attenuates Ventricular Fibrosis through Inhibition of TNF-α in Ovariectomized Rats. Adv Pharmacol Sci 2016 1
35 27209361 Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells. Neuromolecular Med 2016 Sep 2
36 27286684 Using natural products to promote caspase-8-dependent cancer cell death. Cancer Immunol Immunother 2017 Feb 1
37 27393453 In silico binding analysis of Withanolides with the Human GM-CSFR. Pak J Pharm Sci 2016 Jul 3
38 27717869 Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms. Free Radic Biol Med 2016 Dec 1
39 27822364 New withanolides with TRAIL-sensitizing effect from <i>Physalis pubescens</i> L. RSC Adv 2016 1
40 28257574 17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships. J Med Chem 2017 Apr 13 2
41 28350459 STAT3 Inhibitory Activity of Structurally Simplified Withaferin A Analogues. Org Lett 2017 Apr 7 1
42 29371926 A natural inhibitor of kidney-type glutaminase: a withanolide from <i>Physalis pubescens</i> with potent anti-tumor activity. Oncotarget 2017 Dec 26 1
43 29468929 Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer. Cell Cycle 2018 2
44 29491636 Viwithan, a Standardized <i>Withania somnifera</i> Root Extract Induces Apoptosis in Murine Melanoma Cells. Pharmacogn Mag 2018 Jan 3
45 29780684 A new insight into identification of in silico analysis of natural compounds targeting GPR120. Netw Model Anal Health Inform Bioinform 2018 1
46 30579997 In vitro study of Withanolide D toxicity on goat preantral follicles and its effects on the cell cycle. Reprod Toxicol 2019 Mar 1
47 30668401 Different effects of 4β-hydroxywithanolide E and withaferin A, two withanolides from Solanaceae plants, on the Akt signaling pathway in human breast cancer cells. Phytomedicine 2019 Feb 2
48 30808373 Wild type p53 function in p53<sup>Y220C</sup> mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence. J Exp Clin Cancer Res 2019 Feb 26 3
49 31319488 Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway. Molecules 2019 Jul 17 6
50 32899914 Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells. Biomedicines 2020 Sep 6 3