3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer






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1 1348399 Influence of opioids on CSF vasopressin concentration in newborn pigs. Am J Physiol 1992 Mar 1
2 1648591 Kappa-opioid modulation of vasopressin secretion in conscious rats. J Endocrinol 1991 Jun 1
3 1656303 In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus. Neuropharmacology 1991 Jun 1
4 2158952 Synthesis and in vitro characterization of fluorinated U-50488 analogs for PET studies of kappa opioid receptors. Int J Rad Appl Instrum A 1990 1
5 2177159 Kappa-opioid-receptor-mediated regulation of alpha-melanocyte-stimulating hormone secretion and tuberohypophyseal dopaminergic neuronal activity. Neuroendocrinology 1990 Aug 3
6 2559186 Selectivity for opioid receptor subtypes of enkephalin analogues in isolated smooth muscle and in the analgesic effect in mice. J Pharmacobiodyn 1989 Sep 1
7 2841553 The kappa-opioid receptor from human placenta: hydrodynamic characteristics and evidence for its association with a G protein. Life Sci 1988 1
8 2850064 Agonists at mu-opioid, M2-muscarinic and GABAB-receptors increase the same potassium conductance in rat lateral parabrachial neurones. Br J Pharmacol 1988 Nov 1
9 2883617 Antagonism of mu-opioid receptor-mediated inhibitions of nociceptive neurones by U50488H and dynorphin A1-13 in the rat dorsal horn. Neurosci Lett 1987 Mar 31 1
10 2894234 Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat. Brain Res 1987 Dec 15 2
11 2991502 Diuresis and suppression of vasopressin by kappa opioids: comparison with mu and delta opioids and clonidine. J Pharmacol Exp Ther 1985 Aug 1
12 3001566 Opioid kappa receptors and the secretion of prolactin (PRL) and growth hormone (GH) in the rat. II. GH and PRL release-inhibiting effects of the opioid kappa receptor agonists bremazocine and U-50,488. Neuroendocrinology 1986 1
13 3251164 Effect of the opioid kappa-receptor agonist U50488H on the secretion of arginine vasopressin. Study on the mechanism of U50488H-induced diuresis. Neuroendocrinology 1988 Dec 5
14 3326929 Possible mechanism involved in the inhibitory action of U-50, 488H, an opioid kappa agonist, on guinea pig hippocampal CA3 pyramidal neurons in vitro. J Pharmacobiodyn 1987 Oct 1
15 7898309 Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by kappa opioid receptors expressed in Xenopus oocytes. Brain Res Mol Brain Res 1994 Dec 1
16 8045272 U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs. Eur J Pharmacol 1994 May 2 2
17 8393525 Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol Pharmacol 1993 Jul 1
18 8394964 Kappa opioid receptor-mediated regulation of prolactin and alpha-melanocyte-stimulating hormone secretion in male and female rats. Life Sci 1993 1
19 8436965 Long-term opiate exposure leads to increase in synapsin I in rat spinal cord-dorsal root ganglion cocultures. J Neurochem 1993 Mar 2
20 8664348 Inhibition of the expression of ornithine decarboxylase by some kappa-opioidergic receptor ligands in difluoromethylornithine-resistant L1210 cells. Biochim Biophys Acta 1996 May 28 2
21 8846407 Alteration of calcitonin gene related peptide and its receptor binding sites during the development of tolerance to mu and delta opioids. Can J Physiol Pharmacol 1995 Jul 1
22 8938656 Opioid receptor-mediated control of acetylcholine release in human neocortex tissue. Naunyn Schmiedebergs Arch Pharmacol 1996 Nov 2
23 8996223 Dynorphin A1-13 stimulates ovine fetal pituitary-adrenal function through a novel nonopioid mechanism. J Pharmacol Exp Ther 1997 Jan 1
24 9050024 The role of vasopressin on the effect of U-50,488 to block the development of morphine tolerance and physical dependence. Naunyn Schmiedebergs Arch Pharmacol 1997 Feb 1
25 9306249 Synthesis and structure-opioid activity relationships of trans-(+/-)-3,4-dichloro-N-methyl-N-[4- or 5-hydroxy-2-(1-pyrrolidiny)cyclohexyl]benzeneacetamides. J Pharm Pharmacol 1997 Sep 1
26 9746211 Modulation of the induction of ornithine decarboxylase by some opioid receptor agonists in immune cells and cardiomyocytes. Mol Cell Biochem 1998 Aug 3
27 10189065 Augmenting effect of opioids on nitrite production by stimulated murine macrophages. Neuropeptides 1998 Jun 1
28 10497906 Effects of kappa- and mu-opioid receptor agonists on Ca2+ channels in neuroblastoma cells: involvement of the orphan opioid receptor. Eur J Pharmacol 1999 Aug 27 2
29 10607882 The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands. Eur J Pharmacol 1999 Dec 3 10
30 10650139 Blockade of U50488H on sodium currents in acutely isolated mice hippocampal CA3 pyramidal neurons. Brain Res 2000 Feb 7 1
31 10665987 Kappa-opioid receptor stimulation increases the expression of Na+-H+ exchange gene in the heart. Life Sci 2000 1
32 11133354 Cyclic AMP regulates the calcium transients released from IP(3)-sensitive stores by activation of rat kappa-opioid receptors expressed in CHO cells. Cell Calcium 2001 Jan 3
33 11245971 U50488 inhibits HIV-1 expression in acutely infected monocyte-derived macrophages. Drug Alcohol Depend 2001 Apr 1 8
34 11282358 Blockade of U50488H on potassium currents of acutely isolated mouse hippocampal CA3 pyramidal neurons. Brain Res 2001 Apr 6 2
35 11406466 Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 2001 Jul 4
36 11931835 Kappa-opioid receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4(+) lymphocytes. Biochem Pharmacol 2002 Mar 15 2
37 12006360 Site and mechanism of action of dynorphin A-(1-13) and N-methyl-D-aspartate on ACTH release in fetal sheep. Am J Physiol Endocrinol Metab 2002 Jun 1
38 12183679 (-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] induces internalization and down-regulation of the human, but not the rat, kappa-opioid receptor: structural basis for the differential regulation. J Pharmacol Exp Ther 2002 Sep 1
39 12606694 Differential regulation of the human kappa opioid receptor by agonists: etorphine and levorphanol reduced dynorphin A- and U50,488H-induced internalization and phosphorylation. J Pharmacol Exp Ther 2003 May 1
40 12649366 Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. J Pharmacol Exp Ther 2003 Apr 2
41 12706459 Activation of the kappa-opioid receptor in Caco-2 cells decreases interleukin-8 secretion. Eur J Pharmacol 2003 Apr 25 2
42 12715097 Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanisms. Sheng Li Xue Bao 2003 Apr 25 4
43 12721110 Effects of U-50488H and U-50488H withdrawal on c-fos expression in the rat paraventricular nucleus. Correlation with c-fos in brainstem catecholaminergic neurons. Br J Pharmacol 2003 Apr 7
44 12794053 Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages. Ann N Y Acad Sci 2003 May 1
45 12915238 Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys. Brain Res 2003 Aug 22 3
46 15542756 Alpha 7-type nicotinic acetylcholine receptor and prodynorphin mRNA expression after administration of (-)-nicotine and U-50,488H in beta-amyloid peptide (25-35)-treated mice. Ann N Y Acad Sci 2004 Oct 1
47 15953492 Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats. Biol Psychiatry 2005 Jun 15 1
48 16006036 Effect of supraspinal Nocistatin on Nociceptin/Orphanin FQ antagonism of selective opioid analgesia. Neurosci Lett 2005 Oct 28 1
49 16482086 Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. Neuropsychopharmacology 2007 Feb 1
50 16610083 [COX-2 mediates U50488H-induced delayed cardioprotection in isolated rat heart]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2006 Mar 3