artemisinin






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1 2794752 Qinghaosu-mediated oxidation in normal and abnormal erythrocytes. J Lab Clin Med 1989 Oct 1
2 7709742 3D-QSAR study on ether and ester analogs of artemisinin with comparative molecular field analysis. Zhongguo Yao Li Xue Bao 1994 Nov 1
3 8080446 Enhancement of hemin-induced membrane damage by artemisinin. Biochem Pharmacol 1994 Aug 17 2
4 9134741 Stereochemistry-dependent cytotoxicity of some artemisinin derivatives. J Nat Prod 1997 Apr 1
5 9357485 The pharmacokinetics of a single dose of artemisinin in subjects with liver cirrhosis. Bach Mai-Amsterdam Research Group on Artemisinin. Trop Med Int Health 1997 Oct 1
6 9373657 Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam. Trans R Soc Trop Med Hyg 1997 Jul-Aug 1
7 9604124 Artemisinin pharmacokinetics in healthy adults after 250, 500 and 1000 mg single oral doses. Biopharm Drug Dispos 1998 May 1
8 9728896 Artemisinin induces omeprazole metabolism in human beings. Clin Pharmacol Ther 1998 Aug 4
9 9929507 High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement. Drug Metab Dispos 1999 Feb 1
10 10543871 Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. J Med Chem 1999 Oct 21 1
11 10583023 Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin. Br J Clin Pharmacol 1999 Oct 21
12 10626755 Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19. Fundam Clin Pharmacol 1999 6
13 11124226 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos 2001 Jan 1
14 11324528 [The inhibitory effects of artemisinin-derivatives on Na+ and K+ channels in comparison with those of procaine]. Sheng Li Xue Bao 1998 Apr 2
15 11432537 Pharmacokinetic interactions of antimalarial agents. Clin Pharmacokinet 2001 3
16 11575956 Synthesis of new artemisinin analogues from artemisinic acid modified at C-3 and C-13 and their antimalarial activity. J Nat Prod 2001 Sep 2
17 11697139 Proposed reductive metabolism of artemisinin by glutathione transferases in vitro. Free Radic Res 2001 Oct 12
18 11855985 Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues. J Med Chem 2002 Feb 28 1
19 11888669 Transferrin overcomes drug resistance to artemisinin in human small-cell lung carcinoma cells. Cancer Lett 2002 May 28 1
20 12536531 [Inflammatory-inducing effect of lumbar disc tissue: an experimental study]. Hunan Yi Ke Da Xue Xue Bao 2001 Dec 28 1
21 12619052 Characterisation of the human liver in vitro metabolic pattern of artemisinin and auto-induction in the rat by use of nonlinear mixed effects modelling. Biopharm Drug Dispos 2003 Mar 2
22 12643911 Alkylation of manganese(II) tetraphenylporphyrin by antimalarial fluorinated artemisinin derivatives. Bioorg Med Chem Lett 2003 Mar 24 1
23 12844133 Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9. Clin Pharmacol Ther 2003 Jul 6
24 13679021 Turning an 'Achilles' Heel' into an asset--activation of HIF-1alpha during angiostatic therapy will increase tumor sensitivity to iron-catalyzed oxidative damage. Med Hypotheses 2003 Oct 2
25 14615418 The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab Invest 2003 Nov 5
26 14660006 Differential involvement of protein kinase C in human promyelocytic leukemia cell differentiation enhanced by artemisinin. Eur J Pharmacol 2003 Dec 15 6
27 14698358 Postsynaptic dopamine (D(2))-mediated behavioural effects of high acute doses of artemisinin in rodents. Brain Res Bull 2003 Dec 30 3
28 15115411 Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate. J Med Chem 2004 May 6 3
29 15336316 Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med 2004 Oct 1 1
30 15642597 Effects of artemisinin-tagged holotransferrin on cancer cells. Life Sci 2005 Jan 28 4
31 15761118 Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol 2005 Jun 18
32 15782383 C10-modified artemisinin derivatives: efficient heme-alkylating agents. Angew Chem Int Ed Engl 2005 Mar 29 1
33 15878303 Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy. Drug Resist Updat 2005 Feb-Apr 1
34 16019941 Radiolytically induced one-electron reduction of artemisinin in H2O/ethanol (1:1 v/v) solution: a pulse radiolysis study. Int J Radiat Biol 2005 Apr 1
35 16170412 Yeast model uncovers dual roles of mitochondria in action of artemisinin. PLoS Genet 2005 Sep 12
36 16185154 Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds. Expert Opin Ther Targets 2005 Oct 7
37 16261361 Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans. Eur J Clin Pharmacol 2005 Nov 5
38 16412643 The reaction of artemisinins with hemoglobin: a unified picture. Bioorg Med Chem 2006 May 1 1
39 16491843 Homology modeling and molecular docking study of translationally controlled tumor protein and artemisinin. Arch Pharm Res 2006 Jan 1
40 16506047 Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea. Eur J Clin Pharmacol 2006 Apr 2
41 16512009 [The OMS demands an immediate end to the commercialization of antimalarials only consisting of artemisinine]. Rev Med Suisse 2006 Feb 1 1
42 16730793 Study of the interaction of artemisinin with bovine serum albumin. Int J Biol Macromol 2006 Nov 15 2
43 16879742 From chloroquine to artemisinin-based combination therapy: the Sudanese experience. Malar J 2006 Jul 31 1
44 16919048 In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin. Eur J Clin Invest 2006 Sep 12
45 17115150 Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations. Eur J Clin Pharmacol 2007 Jan 1
46 17279482 Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography/mass spectrometry: application to high-throughput inhibition screening of terpenoids. Rapid Commun Mass Spectrom 2007 1
47 17314215 Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology (Oxford) 2007 Jun 1
48 17521300 Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. Fundam Clin Pharmacol 2007 Jun 8
49 18044948 Theoretical study of radical and neutral intermediates of artemisinin decomposition. J Chem Inf Model 2008 Jan 1
50 18223457 Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa. Ther Drug Monit 2008 Feb 1