pyrazolone






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1 611971 [Effect of a diuretically-active pyrazolone derivative on renin activity, plasma angiotensin II and aldesterone concentration in healthy subjects]. Verh Dtsch Ges Inn Med 1977 Apr 17-21 2
2 2151433 [The determination of specific IgE in allergy diagnosis. The clinical significance of specific IgE in drug allergies]. Clin Ter 1990 Dec 31 1
3 3489647 [Immediate-type reactions to pyrazole derivatives: results of skin tests and antibody determinations]. Dermatologica 1986 1
4 3656349 Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogues of imazodan (CI-914). J Med Chem 1987 Oct 1
5 4472458 Drug interactions. II. Binding of some pyrazolone and pyrazolidine derivatives to bovine serum albumin. Chem Pharm Bull (Tokyo) 1974 Jun 1
6 12704373 IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone. J Allergy Clin Immunol 2003 Apr 1
7 14514315 Rhenium(I)-induced cyclization of thiosemicarbazones derived from beta-keto esters. Inorg Chem 2003 Oct 6 1
8 15837310 The development of monocyclic pyrazolone based cytokine synthesis inhibitors. Bioorg Med Chem Lett 2005 May 2 1
9 16043520 Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med 2005 Aug 1 4
10 16460933 Structure-guided identification of novel VEGFR-2 kinase inhibitors via solution phase parallel synthesis. Bioorg Med Chem Lett 2006 Apr 15 1
11 19914068 Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett 2010 Jan 1 1
12 19926937 The pyrazolone originally reported to be a formyl peptide receptor (FPR) 2/ALX-selective agonist is instead an FPR1 and FPR2/ALX dual agonist. J Pharmacol Sci 2009 Nov 7
13 20534345 Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol 2010 May 28 1
14 21201166 A second monoclinic polymorph of 4-(2-hydr-oxy-4-methoxy-benzyl-ideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one. Acta Crystallogr Sect E Struct Rep Online 2008 Sep 20 1
15 22061645 Pyrazolone-based anaplastic lymphoma kinase (ALK) inhibitors: control of selectivity by a benzyloxy group. Bioorg Med Chem Lett 2011 Dec 15 2
16 22154351 Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett 2012 Jan 1 2
17 22320327 Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series. J Med Chem 2012 Mar 8 3
18 22320343 Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives. J Med Chem 2012 Mar 8 1
19 23125802 (Z)-3-Methyl-1-phenyl-4-[(p-tol-yl)(p-tolyl-amino)-methyl-idene]-1H-pyrazol-5(4H)-one. Acta Crystallogr Sect E Struct Rep Online 2012 Oct 1 1
20 23160941 Functional characterization of three mouse formyl peptide receptors. Mol Pharmacol 2013 Feb 1
21 23528231 Characterization of a new mPGES-1 inhibitor in rat models of inflammation. Prostaglandins Other Lipid Mediat 2013 Apr-May 1
22 24607578 Development of novel pyrazolone derivatives as inhibitors of aldose reductase: an eco-friendly one-pot synthesis, experimental screening and in silico analysis. Bioorg Chem 2014 Apr 2
23 24636540 Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivatives as selective COX-2 inhibitors: molecular docking study. Chem Biol Drug Des 2014 Oct 2
24 25173590 Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents. Bioorg Chem 2014 Dec 1
25 25182962 Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Bioorg Med Chem 2014 Oct 1 2
26 25765567 The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives. Br J Pharmacol 2015 Jul 2
27 25977593 Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1). Tetrahedron Lett 2015 May 20 1
28 26186011 Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis. J Med Chem 2015 Aug 13 1
29 26328495 POMGNT1 Is Glycosylated by Mucin-Type O-Glycans. Biol Pharm Bull 2015 1
30 28411406 Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors. Bioorg Chem 2017 Jun 4
31 29216268 Docking and quantitative structure-activity relationship of bi-cyclic heteroaromatic pyridazinone and pyrazolone derivatives as phosphodiesterase 3A (PDE3A) inhibitors. PLoS One 2017 2
32 30653296 NHC-Catalyzed Generation of α,β-Unsaturated Acylazoliums for the Enantioselective Synthesis of Heterocycles and Carbocycles. Acc Chem Res 2019 Feb 19 1
33 30990358 Biological evaluation, molecular docking and DNA interaction studies of coordination compounds gleaned from a pyrazolone incorporated ligand. Nucleosides Nucleotides Nucleic Acids 2019 1
34 31498340 Copper-catalyzed enantioselective alkynylation of pyrazole-4,5-diones with terminal alkynes. Chem Commun (Camb) 2019 Sep 24 1
35 31670091 Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers. Int Immunopharmacol 2019 Dec 1
36 31740202 Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity. Bioorg Med Chem 2020 Jan 1 2
37 32031284 Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim) 2020 Apr 2
38 32841430 Novel thiazole-pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction. Arch Pharm (Weinheim) 2020 Dec 3
39 33210922 From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. J Med Chem 2020 Dec 10 1
40 33705897 A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A. Bioorg Med Chem Lett 2021 May 15 1
41 33945231 Highly Diastereoselective Hydrosilane-Assisted Rhodium-Catalyzed Spiro-Type Cycloisomerization of Succinimide and Pyrazolone-Based Functional 1,6-Dienes. Chem Asian J 2021 Jul 5 1
42 33965840 Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells. Bioorg Med Chem 2021 Jun 15 6
43 33979735 Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction. Bioorg Chem 2021 Jul 3
44 34007088 Design and synthesis of pyrazolone-based compounds as potent blockers of SARS-CoV-2 viral entry into the host cells. J Mol Struct 2021 Oct 5 1
45 35429911 Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction. Eur J Med Chem 2022 Jun 5 1