Title : Pentosan polysulfate decreases proliferation and net extracellular matrix production in mouse mesangial cells.

Pub. Date : 1999 Jan

PMID : 9890310






4 Functional Relationships(s)
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1 Cells treated with PPS showed a decrease in cell number beginning 24 h after treatment, which was maintained for 5 d. For matrix accumulation and degradation studies, cells were treated for 5 d and collagen types I and IV protein were measured by enzyme-linked immunosorbent assay as well as matrix metalloproteinases (MMP) measured by zymography. Pentosan Sulfuric Polyester matrix metallopeptidase 2 Mus musculus
2 By zymography, MMP-2 was significantly increased after treatment with PPS (P < 0.001) and heparin (P < 0.05). Pentosan Sulfuric Polyester matrix metallopeptidase 2 Mus musculus
3 By zymography, MMP-2 was significantly increased after treatment with PPS (P < 0.001) and heparin (P < 0.05). Heparin matrix metallopeptidase 2 Mus musculus
4 In conclusion, PPS alters extracellular matrix turnover through the induction of MMP-2 and alterations in the TIMP profile and may be useful in decreasing progressive glomerulosclerosis. Pentosan Sulfuric Polyester matrix metallopeptidase 2 Mus musculus