Title : Association of N- and C-terminal domains of phospholipase D is required for catalytic activity.

Pub. Date : 1998 Dec 25

PMID : 9856987






2 Functional Relationships(s)
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1 Deletion mutants of rPLD1 that contained only an N- or C-terminal HKD domain exhibited no catalytic activity when expressed in COS 7 cells. carbonyl sulfide phospholipase D1 Rattus norvegicus
2 In addition, deletion of 168 amino acids from the N terminus of rPLD1 significantly enhanced basal PLD activity while inhibiting the response to phorbol ester. Phorbol Esters phospholipase D1 Rattus norvegicus