Pub. Date : 1998 Nov
PMID : 9808636
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vitamin A is a potent inducer for liver/bone/kidney alkaline phosphatase (L/B/K ALP) in a variety of tissues. | Vitamin A | PDZ and LIM domain 3 | Rattus norvegicus |
| 2 | However, the evidence for induction of L/B/K ALP by vitamin A in small intestine is limited. | Vitamin A | PDZ and LIM domain 3 | Rattus norvegicus |
| 3 | In this study, we investigated the influence of vitamin A on L/B/K ALP expression in rat small intestinal crypt IEC-6 cells and fetal rat small intestine. | Vitamin A | PDZ and LIM domain 3 | Rattus norvegicus |
| 4 | Treatment of IEC-6 cells with all-trans retinoic acid (RA) increased the levels of activity, protein and mRNA of L/B/K ALP, whereas enterocyte-specific proteins, including intestinal ALP, sucrase-isomaltase and glucose transporter-2, were not induced. | Tretinoin | PDZ and LIM domain 3 | Rattus norvegicus |
| 5 | Treatment of IEC-6 cells with all-trans retinoic acid (RA) increased the levels of activity, protein and mRNA of L/B/K ALP, whereas enterocyte-specific proteins, including intestinal ALP, sucrase-isomaltase and glucose transporter-2, were not induced. | Tretinoin | PDZ and LIM domain 3 | Rattus norvegicus |
| 6 | Our results suggest that vitamin A may be an important regulator for L/B/K ALP expression in fetal rat small intestine as well as in IEC-6 cells. | Vitamin A | PDZ and LIM domain 3 | Rattus norvegicus |