Pub. Date : 1998 Nov 3
PMID : 9799212
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS AND RESULTS: We constructed a recombinant adenovirus, Ad.nNOS, that expresses the neuronal isoform of NOS (nNOS) and used it for in vivo endovascular gene transfer to carotid arteries (CA) from normal and cholesterol-fed rabbits. | Cholesterol | nitric oxide synthase, brain | Oryctolagus cuniculus |
| 2 | METHODS AND RESULTS: We constructed a recombinant adenovirus, Ad.nNOS, that expresses the neuronal isoform of NOS (nNOS) and used it for in vivo endovascular gene transfer to carotid arteries (CA) from normal and cholesterol-fed rabbits. | Cholesterol | nitric oxide synthase, brain | Oryctolagus cuniculus |
| 3 | Ad.nNOS gene transfer also significantly enhanced endothelium-dependent vascular relaxation to acetylcholine; at 3 micromol/L acetylcholine, Ad.nNOS-treated arteries showed an 86+/-4% reduction in precontracted tension, whereas control CA showed a 47+/-6% reduction in tension. | Acetylcholine | nitric oxide synthase, brain | Oryctolagus cuniculus |
| 4 | Ad.nNOS gene transfer also significantly enhanced endothelium-dependent vascular relaxation to acetylcholine; at 3 micromol/L acetylcholine, Ad.nNOS-treated arteries showed an 86+/-4% reduction in precontracted tension, whereas control CA showed a 47+/-6% reduction in tension. | Acetylcholine | nitric oxide synthase, brain | Oryctolagus cuniculus |
| 5 | Ad.nNOS gene transfer also significantly enhanced endothelium-dependent vascular relaxation to acetylcholine; at 3 micromol/L acetylcholine, Ad.nNOS-treated arteries showed an 86+/-4% reduction in precontracted tension, whereas control CA showed a 47+/-6% reduction in tension. | Acetylcholine | nitric oxide synthase, brain | Oryctolagus cuniculus |
| 6 | Ad.nNOS gene transfer also significantly enhanced endothelium-dependent vascular relaxation to acetylcholine; at 3 micromol/L acetylcholine, Ad.nNOS-treated arteries showed an 86+/-4% reduction in precontracted tension, whereas control CA showed a 47+/-6% reduction in tension. | Acetylcholine | nitric oxide synthase, brain | Oryctolagus cuniculus |
| 7 | The CA from cholesterol-fed rabbits showed impaired acetylcholine-induced relaxation, but this abnormality was almost entirely corrected by Ad.nNOS gene transfer. | Cholesterol | nitric oxide synthase, brain | Oryctolagus cuniculus |