Pub. Date : 1998
PMID : 9760691
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compounds containing fluorine in the terminal positions of the alkyl chain retained sPLA2 inhibitory activity and also possessed improved in vitro metabolic stability and pharmacokinetic parameters relative to nonfluorinated inhibitors in this series. | Fluorine | phospholipase A2 group IIA | Rattus norvegicus |
| 2 | In fact, the results for GW 9624 and GW 8219 suggested that factors in addition to potency of sPLA2 inhibition and metabolism affect the observed in vivo activity. | glycyltryptophan | phospholipase A2 group IIA | Rattus norvegicus |
| 3 | In fact, the results for GW 9624 and GW 8219 suggested that factors in addition to potency of sPLA2 inhibition and metabolism affect the observed in vivo activity. | glycyltryptophan | phospholipase A2 group IIA | Rattus norvegicus |