Title : Hemodialysis for severe procainamide toxicity: clinical and pharmacokinetic observations.

Pub. Date : 1976 Nov

PMID : 975731






2 Functional Relationships(s)
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1 Hemodialysis doubled the rate of procainamide elimination and increased fourfold the clearance of NAPA, the N-acetylated metabolite of procainamide. Procainamide NSF attachment protein alpha Homo sapiens
2 Observations of procainamide and N-acetylprocainamide (NAPA) plasma levels during the patient"s recovery suggest that lethargy and profound hypotension can be expected when these levels total 60 mug/ml and that severe cardiac toxicity should be anticipated with levels totaling 42 mug/ml or more. Acecainide NSF attachment protein alpha Homo sapiens