Pub. Date : 1998 Aug 27
PMID : 9734482
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estradiol 17-beta represses insulin-like growth factor I receptor expression in smooth muscle cells from rabbit cardiac recipients. | Estradiol | insulin-like growth factor I | Oryctolagus cuniculus |
| 2 | Earlier, we found estradiol 17-beta treatment of cardiac allograft recipients attenuates transplant arteriosclerosis; this was associated with inhibition of vascular cell proliferation induced by IGF-I. | Estradiol | insulin-like growth factor I | Oryctolagus cuniculus |
| 3 | RESULTS: Estradiol 17-beta treatment of rabbits significantly inhibited IGF-IR expression in the allograft coronary arteries and abrogated cell proliferation induced by IGF-I in the allograft aorta compared with placebo-treated recipients (65.4+/-5% vs. 500+/-139%, P<0.002). | Estradiol | insulin-like growth factor I | Oryctolagus cuniculus |