Title : In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor.

Pub. Date : 1998 Sep

PMID : 9696850






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Furthermore, this p7/p1 mutation was present in all clones obtained from passage P17 (3.0 microM ABT-378) onward and always occurred in conjunction with the p1/p6 mutation. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid crystallin gamma F, pseudogene Homo sapiens
2 This suggests that mutation of these gag proteolytic cleavage sites is required for the growth of highly resistant HIV-1 selected by ABT-378 and supports recent work demonstrating that mutations in the p7/p1/p6 region play an important role in conferring resistance to protease inhibitors (L. Doyon et al., J. Virol. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid crystallin gamma F, pseudogene Homo sapiens