Title : Syk activation is required for spreading and H2O2 release in adherent human neutrophils.

Pub. Date : 1998 May 15

PMID : 9590268






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Paxillin is a cytoskeletally associated protein that is also tyrosine phosphorylated during PMN spreading and H2O2 release. Tyrosine paxillin Homo sapiens
2 Paxillin is a cytoskeletally associated protein that is also tyrosine phosphorylated during PMN spreading and H2O2 release. Hydrogen Peroxide paxillin Homo sapiens
3 Paxillin phosphorylation is kinetically slower than Syk phosphorylation and is inhibited with piceatannol, suggesting that paxillin is a substrate for Syk. 3,3',4,5'-tetrahydroxystilbene paxillin Homo sapiens
4 Paxillin phosphorylation is kinetically slower than Syk phosphorylation and is inhibited with piceatannol, suggesting that paxillin is a substrate for Syk. 3,3',4,5'-tetrahydroxystilbene paxillin Homo sapiens
5 These results indicate that PMN spreading and H2O2 release require a Syk-dependent signaling pathway leading to paxillin phosphorylation. Hydrogen Peroxide paxillin Homo sapiens