Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization.

Pub. Date : 1998 May

PMID : 9580627






2 Functional Relationships(s)
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1 The antinociceptive effects of ABT-594 in the hot box and formalin tests were attenuated by pretreatment with the nAChR antagonist, mecamylamine, and in animals treated with the nAChR antagonist chlorisondamine, given centrally (10 micrograms/rat i.c.v. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus
2 The antinociceptive effects of ABT-594 in the hot box and formalin tests were attenuated by pretreatment with the nAChR antagonist, mecamylamine, and in animals treated with the nAChR antagonist chlorisondamine, given centrally (10 micrograms/rat i.c.v. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus