Title : Cytosolic phospholipase A2 is required for cytokine-induced expression of type IIA secretory phospholipase A2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts.

Pub. Date : 1998 Jan 16

PMID : 9430720






3 Functional Relationships(s)
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1 Delayed PGE2 generation was also suppressed markedly by the cPLA2 inhibitor arachidonoyl trifluoromethyl ketone (AACOCF3), which attenuated induction of type IIA sPLA2, but not COX-2, expression. Dinoprostone phospholipase A2 group IIA Rattus norvegicus
2 Delayed PGE2 generation was also suppressed markedly by the cPLA2 inhibitor arachidonoyl trifluoromethyl ketone (AACOCF3), which attenuated induction of type IIA sPLA2, but not COX-2, expression. arachidonoyl trifluoromethyl ketone phospholipase A2 group IIA Rattus norvegicus
3 AACOCF3 inhibited the initial phase of cytokine-stimulated arachidonic acid release, and supplementing AACOCF3-treated cells with exogenous arachidonic acid partially restored type IIA sPLA2 expression. Arachidonic Acid phospholipase A2 group IIA Rattus norvegicus