Title : A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin.

Pub. Date : 1997 Sep

PMID : 9409631






1 Functional Relationships(s)
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1 His immediate family members, who were heterozygous for the CYP2A6*2 allele, excreted little 2-hydroxyphenylacetic acid and mainly 7-hydroxycoumarin, when similarly tested. 7-hydroxycoumarin cytochrome P450 family 2 subfamily A member 6 Homo sapiens