Title : Structural and functional roles of modules in hemoglobin. Substitution of module M4 in hemoglobin subunits.

Pub. Date : 1997 Nov 28

PMID : 9374481






1 Functional Relationships(s)
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1 Based on tryptophan fluorescence spectra and computer modeling from x-ray structures of native globins, steric constraint between Trp14 and Tyr125 would be induced in the chimeric alphaalphabeta-subunit, which would perturb the packing of the A- and H-helices and destabilize the globule structure. Tryptophan thioredoxin domain containing 17 Homo sapiens