Title : A novel point mutation of thyroid hormone receptor beta gene in a family with resistance to thyroid hormone.

Pub. Date : 1997 Oct

PMID : 9349582






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We found a novel point mutation of the TRbeta gene in a family (F123) with RTH, a transition of a guanine to adenine at nucleotide 1215, which replaced the normal Met-310 with Ile. Guanine T cell receptor beta locus Homo sapiens
2 We found a novel point mutation of the TRbeta gene in a family (F123) with RTH, a transition of a guanine to adenine at nucleotide 1215, which replaced the normal Met-310 with Ile. Adenine T cell receptor beta locus Homo sapiens
3 In vitro transcription and translation of this mutant TRbeta demonstrated a 12-fold reduction of the affinity for triiodothyronine (T3) compared with the wild type TRbeta. Triiodothyronine T cell receptor beta locus Homo sapiens
4 In vitro transcription and translation of this mutant TRbeta demonstrated a 12-fold reduction of the affinity for triiodothyronine (T3) compared with the wild type TRbeta. Triiodothyronine T cell receptor beta locus Homo sapiens