Title : Expression of transcription factors during sodium phenylacetate induced erythroid differentiation in K562 cells.

Pub. Date : 1997

PMID : 9215748






2 Functional Relationships(s)
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1 During 15 days of treatment of K562 cells with sodium phenylacetate, we observed an increase in the cellular hemoglobin concentration with a similar increase in the expression of gamma-globin mRNA. phenylacetic acid hemoglobin subunit gamma 1 Homo sapiens
2 We conclude that sodium phenylacetate treatment of K562 cells increases gamma-globin mRNA and induces cell maturation as judged by morphology without affecting the expression of the erythroid transcription factors, some of which are known to be involved in the regulation of beta-like globin genes. phenylacetic acid hemoglobin subunit gamma 1 Homo sapiens