Title : Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production.

Pub. Date : 1997 Jun 15

PMID : 9192787






2 Functional Relationships(s)
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1 Folate-deficient erythroblasts cultured in folate-deficient medium had marked decreases in all coenzyme forms of folate that persisted throughout culture, increased uracil misincorporation into DNA, persistent accumulations of p53 and p21, and decreased reticulocyte production but increased size of individual reticulocytes. Folic Acid cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
2 Folate-deficient erythroblasts cultured in folate-deficient medium had marked decreases in all coenzyme forms of folate that persisted throughout culture, increased uracil misincorporation into DNA, persistent accumulations of p53 and p21, and decreased reticulocyte production but increased size of individual reticulocytes. Folic Acid cyclin-dependent kinase inhibitor 1A (P21) Mus musculus